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Direct linkGiovanna Cantini Tolezano; Giovanna Civitate Bastos; Silvia Souza da Costa; Bruna Lucheze Freire; Thais Kataoka Homma; Rachel Sayuri Honjo; Guilherme Lopes Yamamoto; Maria Rita Passos-Bueno; Celia Priszkulnik Koiffmann; Chong Ae Kim; Angela Maria Vianna-Morgante; Alexander Augusto de Lima Jorge; Débora Romeo Bertola; Carla Rosenberg; Ana Cristina Victorino Krepischi – Journal of Autism and Developmental Disorders, 2024
Microcephaly presents heterogeneous genetic etiology linked to several neurodevelopmental disorders (NDD). Copy number variants (CNVs) are a causal mechanism of microcephaly whose investigation is a crucial step for unraveling its molecular basis. Our purpose was to investigate the burden of rare CNVs in microcephalic individuals and to review…
Descriptors: Foreign Countries, Genetics, Genetic Disorders, Neurodevelopmental Disorders
Stuart, Nicole; Whitehouse, Andrew; Palermo, Romina; Bothe, Ellen; Badcock, Nicholas – Journal of Autism and Developmental Disorders, 2023
Reduced eye contact early in life may play a role in the developmental pathways that culminate in a diagnosis of autism spectrum disorder. However, there are contradictory theories regarding the neural mechanisms involved. According to the amygdala theory of autism, reduced eye contact results from a hypoactive amygdala that fails to flag eyes as…
Descriptors: Literature Reviews, Nonverbal Communication, Autism Spectrum Disorders, Child Development
Christiana Butera; Jonathan Delafield-Butt; Szu-Ching Lu; Krzysztof Sobota; Timothy McGowan; Laura Harrison; Emily Kilroy; Aditya Jayashankar; Lisa Aziz-Zadeh – Journal of Autism and Developmental Disorders, 2025
Autism spectrum disorder (ASD) and Developmental Coordination Disorder (DCD) are distinct clinical groups with overlapping motor features. We attempted to (1) differentiate children with ASD from those with DCD, and from those typically developing (TD) (ages 8-17; 18 ASD, 16 DCD, 20 TD) using a 5-min coloring game on a smart tablet and (2)…
Descriptors: Autism Spectrum Disorders, Developmental Disabilities, Psychomotor Skills, Children
Zarakoviti, Eleni; Shafran, Roz; Skuse, David; McTague, Amy; Batura, Neha; Palmer, Tom; Dalrymple, Emma; Bennett, Sophie D.; Reilly, Colin – Journal of Autism and Developmental Disorders, 2023
This systematic review aimed to identify factors significantly associated with the occurrence of epilepsy in autistic individuals and to consider the impact of study quality on findings. Electronic databases were systematically searched on October 2nd, 2020 and records retrieved were limited to those published from 2000 onwards. Study quality was…
Descriptors: Epilepsy, Autism Spectrum Disorders, Comorbidity, Correlation
Keary, Christopher J.; Mullett, Jennifer E.; Nowinski, Lisa; Wagner, Karyn; Walsh, Briana; Saro, Hannah K.; Erhabor, Gillian; Thibert, Ronald L.; McDougle, Christopher J.; Ravichandran, Caitlin T. – Journal of Autism and Developmental Disorders, 2022
Anxiety is being increasingly identified in Angelman syndrome (AS). Qualitative questions and quantitative assessments were used to evaluate for anxiety in 50 subjects with AS. In-person evaluations assessed behaviors concerning for anxiety and circumstances wherein they occurred. Caregivers completed anxiety and other behavioral rating scales.…
Descriptors: Anxiety, Genetic Disorders, Neurological Impairments, Caregivers
Dorinde M. van Andel; Jan J. Sprengers; Marsh Königs; Maretha V. de Jonge; Hilgo Bruining – Journal of Autism and Developmental Disorders, 2024
We present the secondary-analysis of neurocognitive tests in the "Bumetanide in Autism Medication and Biomarker" (BAMBI;EUDRA-CT-2014-001560-35) study, a randomized double-blind placebo-controlled (1:1) trial testing 3-months bumetanide treatment ([less than or equal to] 1 mg twice-daily) in unmedicated children 7-15 years with ASD.…
Descriptors: Autism Spectrum Disorders, Drug Therapy, Children, Early Adolescents
Pobric, Gorana; Taylor, Jason R.; Ramalingam, Hemavathy M.; Pye, Emily; Robinson, Louise; Vassallo, Grace; Jung, JeYoung; Bhandary, Misty; Szumanska-Ryt, Karolina; Theodosiou, Louise; Evans, D. Gareth; Eelloo, Judith; Burkitt-Wright, Emma; Hulleman, Johan; Green, Jonathan; Garg, Shruti – Journal of Autism and Developmental Disorders, 2022
Neurofibromatosis 1 (NF1) is a single gene disorder associated with working Memory (WM) impairments. The aim of this study was to investigate P300 event-related potential (ERP) associated with WM in NF1. Sixteen adolescents with NF1 were compared with controls on measures of WM and EEG was recorded during a WM nback task. The NF1 group showed…
Descriptors: Short Term Memory, Neurological Impairments, Genetic Disorders, Adolescents
Zhu, Jiang; Hua, Xueying; Yang, Ting; Guo, Min; Li, Qiu; Xiao, Lu; Li, Ling; Chen, Jie; Li, Tingyu – Journal of Autism and Developmental Disorders, 2022
Metabolic disturbance may be implicated in the pathogenesis of autism. This study aimed to investigate the gut metabolomic profiles of autistic children and to analyze potential interaction between gut metabolites with autistic symptoms and neurodevelopment levels. We involved 120 autistic and 60 neurotypical children. Autistic symptoms and…
Descriptors: Metabolism, Autism, Pervasive Developmental Disorders, Children
Cora E. Mukerji; John S. Wilson III; Carol L. Wilkinson; Manon A. Krol; Charles A. Nelson; Helen Tager-Flusberg – Journal of Autism and Developmental Disorders, 2025
Previous research links resting frontal gamma power to key developmental outcomes in young neurotypical (NT) children and infants at risk for language impairment. However, it remains unclear whether gamma power is specifically associated with language or with more general cognitive abilities among young children diagnosed with autism spectrum…
Descriptors: Brain Hemisphere Functions, Language Impairments, Neurological Impairments, Young Children
Fry, Regan; Li, Xian; Evans, Travis C.; Esterman, Michael; Tanaka, James; DeGutis, Joseph – Journal of Autism and Developmental Disorders, 2023
Autism traits are common exclusionary criteria in developmental prosopagnosia (DP) studies. We investigated whether autism traits produce qualitatively different face processing in 43 DPs with high vs. low autism quotient (AQ) scores. Compared to controls (n = 27), face memory and perception were similarly deficient in the high- and low-AQ DPs,…
Descriptors: Autism Spectrum Disorders, Symptoms (Individual Disorders), Neurological Impairments, Human Body
Zheng, Zhen; Zheng, Peng; Zou, Xiaobing – Journal of Autism and Developmental Disorders, 2021
The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was…
Descriptors: Metabolism, Autism, Pervasive Developmental Disorders, Meta Analysis
Li, Jinglun; Chen, Xiu; Zheng, Ruwen; Chen, Ai; Zhou, Yan; Ruan, Jianghai – Journal of Autism and Developmental Disorders, 2022
Autism spectrum disorder (ASD) is a neurodevelopmental disorder. The associations between the cerebellum and clinical traits remain unclear. We performed amplitude of low-frequency fluctuation (ALFF) analysis to explore the associations between spontaneous brain activity and clinical traits. 361 juvenile ASD patients were included from the ABIDEII…
Descriptors: Autism, Pervasive Developmental Disorders, Brain, Symptoms (Individual Disorders)
Edmunds, Sarah R.; Colman, Carly; Vidal, Paige; Faja, Susan – Journal of Autism and Developmental Disorders, 2022
Deficits in working memory have not been fully explored in toddlers and preschoolers with autism spectrum disorder (ASD). We investigated the relationship between language (verbal ability, verbal self-talk) and visuospatial working memory in 2- and 4-year-olds with ASD (n = 65) and typical development (TD) (n = 54). Children with ASD displayed…
Descriptors: Language Processing, Short Term Memory, Neurological Impairments, Toddlers
Sung, Ming-Chih; Ku, Byungmo; Leung, Willie; MacDonald, Megan – Journal of Autism and Developmental Disorders, 2022
The current meta-analysis comprehensively examined the effects of physical activity interventions on executive function among people with neurodevelopmental disorders. The meta-analysis included 34 studies with 1058 participants aged 5-33 years. Results indicated an overall significant medium effect of physical activity interventions on improving…
Descriptors: Physical Activities, Intervention, Executive Function, Neurological Impairments
Gomathi, Mohan; Padmapriya, Subramanian; Balachandar, Vellingiri – Journal of Autism and Developmental Disorders, 2020
Drug studies on Rett syndrome (RTT) have drastically increased over the past few decades. This review aims to provide master data on bench-to-bedside drug studies involving RTT. A comprehensive literature review was performed by searching in PUBMED, MEDLINE and Google Scholar, international, national and regional clinical trial registries and…
Descriptors: Genetic Disorders, Neurological Impairments, Drug Therapy, Symptoms (Individual Disorders)
