Mathematics education forms the foundational framework for cultivating crucial skills and competencies vital for navigating an ever more intricate and numerical society. Despite its significance, students often encounter challenges and express reluctance towards certain mathematical topics, thus warranting a deeper exploration into the factors influencing students' learning experiences. However, within mathematics, there often exist topics that students least preferred. The research used mixed method, which follows a sequential-explanatory design. The respondents and participants are First Year Nursing Students since these are the students with Biostatistics in its curriculum. The results show that the least preferred topics of the students are the lessons on measures of variability and growth models. This can be explained by the experience of students having information overload where limited time was given to master the lessons. That is why it is recommended for teachers to execute creative and innovative strategies to help students enjoy even the hardest topics in Math 100N.