The main topics of this dissertation are: 1) the development and discussion of a new molecular balance for measuring alkyl-alkyl interactions in a wide array of organic solvents, 2) the development of linear solvation energy relationships between solvent interaction parameters and solvent accessible surface area (SASA) in CH-arene interactions,…

Organic chemistry is accepted as a crucial part of science higher education funneling students into many career opportunities such as pharmaceuticals, biotechnology, and medical industries. Students attempting organic chemistry courses in higher education are among a plethora of majors including biology, chemistry, health science, and engineering.…

Resonance is a fundamental chemistry concept first introduced to students in General Chemistry I, reintroduced in Organic Chemistry I, and then utilized throughout other higher-level chemistry courses. A molecule or ion can be said to exhibit resonance when it can be represented by two or more chemical structures (i.e., Lewis structures) that…

The work presented in the following chapters was undertaken with the goal of understanding and improving education in organic chemistry. Initial work, described in Chapters 1 and 2, focuses on students' ability to explain and rationalize the outcomes of organic chemistry reactions. Chapter 1 explores the relationship between assessment emphasis…

There has been a growing emphasis on integrating green and sustainable chemistry (GSC) into the curriculum. Unfortunately, there is yet to be a nationwide, uniform decision of which aspects should be included or how, leaving individual instructors or institutions to decide whether--and how--to address GSC knowledge. Furthermore, faculty nationwide…

At the molecular level, chemical processes involve the rearrangement of atoms in space and time. Students often struggle with visualizing the 3D spatial characteristics of molecules and transition states, as well as recognizing the dynamic nature of chemistry. Both visual spatial skills and representational competence should be explicitly trained…

Chemistry students often struggle in organic chemistry courses. In fact, these courses are viewed by some as "weed-out" classes. There are many fundamental concepts covered in general chemistry that contribute to students' ability to succeed in organic chemistry. One of those fundamental topics, and the focus of this study, is the topic…

Molecular representations that show chemical bonding are ubiquitous in general and organic chemistry. These help in communicating chemistry concepts that are fundamental to understanding "how" and "why" molecules interact. The goal of this dissertation work is to offer an evidence-based report on the affordances and limitations…

The work in this dissertation is presented in two parts. The first part (Chapters 3 and 4) details work relating to students' explanations of reaction mechanisms in organic chemistry. The second part (Chapters 5 and 6) details work relating to the evaluating the uptake of research-based instructional practices in introductory chemistry,…

Heavy metals are a recognized toxic environmental contaminant, even at very low concentrations. There have been well-known events in the last decade within the US of high amounts of lead in the drinking water supplies of cities, leading to detrimental effects within its population. Ways have been found to remove this metal, and others, from water…

Organic chemistry is a class well known to be difficult and necessary for many careers in the sciences, and as a result, has garnered interest in researching ways to improve student learning and comprehension. One potential way involves using eye tracking techniques to understand how students visually examine questions. Organic chemistry involves…

My thesis work is focused on conceptual and epistemic learning and characterizing the environments in which this learning takes place. Earlier studies conducted by the Stowe group explored how instructional practices, instructional emphasis, and assessment emphasis relate to student outcomes in general and organic chemistry courses. Student…

The dissertation is composed of two main parts. The first half describes efforts to study amyloid peptides using macrocyclic peptide model systems, and the potential deleterious effects of uronium peptide coupling agents on human health. The second half focuses on my experience in chemistry teaching and the chemical education research I conducted.…

I have created a general workflow that describes how students reason through non-trivial organic predict-the-product problems. This was accomplished through an iterative process that combined the experiences of instructors with holistic impressions of think-aloud interviews, incorporating feedback from both undergraduate focus groups and graduate…

Effectively mastering organic chemistry means having the ability to recognize structural patterns, identify properties or behaviors as a result of patterns, manipulate and transform representations, and predict future outcomes. Often students rely on rote memorization of seemingly disconnected information instead of developing a sound…