Describes recent attempts to program computers to map synthetic routes to organic compounds. The computer is provided with structural information for many molecules and reaction descriptions; when a target compound is specified, the computer lists possible precursors, thus indicating possible synthetic routes. (MLH)

There are two conflicting views about the mechanism of 1,3-dipolar cycloadditions to multibonds. To reconcile these viewpoints a concerted, spin-paired, diradical mechanism, based on valence bond theory, is proposed. Each of these three mechanisms is discussed. (JN)

Discusses factors which control rate and orientation of free radical addition to alkenes. Although based primarily on results involving behavior of alkyl radicals, arguments developed apply to addition of atoms and hetero-radicals to olefins. (JN)

Presents (for a broad chemistry relationship) information on solvation energies and their role in determining the course of reactions in solution. Also provides some simple "ground rules" for understanding and predicting solvation effects. (JN)

Discusses the molecular features common to compounds which taste sweet. Particular emphasis is placed on the hydrogen bonding evident in these chemicals. (TS)

Concerted reactions occur in only one step and thus present special problems in the study of their reaction mechanisms. Concertedness can be established with certainty only from a detailed description of the transition state. (Author/TS)

Describes procedures suitable for student preparation of benzaldehyde, benzoic acid, and ethyl benzoate sequentially from benzyl alcohol. Preparation for benzyl chloride also given. All reagents except benzyl alcohol are common inorganic chemicals. (AL)

Explains the reason that chemistry of carbon using principles of bonding, thermodynamics, and kinetics is considered a better introduction to organic chemistry than conventional use of interconversions. (DS)

A discussion is presented of the toxicity, chemistry, and environmental presence of nitrosamines. Carcinogenicity and effects on various organs of test animals are reviewed. Also some information on the presence of use of nitrosamines in human food is given. (MR)

Discusses the synthesis of ethylene glycol from carbon monoxide and hydrogen using bimetallic catalysts. Although this technology has not been implemented, it illustrates two important future trends, namely, use of bimetallic catalysts and use of coal-derived carbon monoxide and hydrogen as a new feed stock. (JN)