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Direct linkPiepho, Hans-Peter; Madden, Laurence V. – Research Synthesis Methods, 2022
Network meta-analysis is a popular method to synthesize the information obtained in a systematic review of studies (e.g., randomized clinical trials) involving subsets of multiple treatments of interest. The dominant method of analysis employs within-study information on treatment contrasts and integrates this over a network of studies. One…
Descriptors: Medical Research, Meta Analysis, Networks, Drug Therapy
Kim, Mi-Ok; Wang, Xia; Liu, Chunyan; Dorris, Kathleen; Fouladi, Maryam; Song, Seongho – Research Synthesis Methods, 2017
Phase I trials aim to establish appropriate clinical and statistical parameters to guide future clinical trials. With individual trials typically underpowered, systematic reviews and meta-analysis are desired to assess the totality of evidence. A high percentage of zero or missing outcomes often complicate such efforts. We use a systematic review…
Descriptors: Meta Analysis, Synthesis, Literature Reviews, Pediatrics
