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Naturalistic Language Recordings Reveal "Hypervocal" Infants at High Familial Risk for Autism
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Swanson, Meghan R.; Shen, Mark D.; Wolff, Jason J.; Boyd, Brian; Clements, Mark; Rehg, James; Elison, Jed T.; Paterson, Sarah; Parish-Morris, Julia; Chappell, J. Chad; Hazlett, Heather C.; Emerson, Robert W.; Botteron, Kelly; Pandey, Juhi; Schultz, Robert T.; Dager, Stephen R.; Zwaigenbaum, Lonnie; Estes, Annette M.; Piven, Joseph – Child Development, 2018
Children's early language environments are related to later development. Little is known about this association in siblings of children with autism spectrum disorder (ASD), who often experience language delays or have ASD. Fifty-nine 9-month-old infants at high or low familial risk for ASD contributed full-day in-home language recordings.…
Descriptors: Infants, Autism, Pervasive Developmental Disorders, Environmental Influences
From Genes to Environment: Using Integrative Genomics to Build a "Systems-Level" Understanding of Autism Spectrum Disorders
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Hu, Valerie W. – Child Development, 2013
Autism spectrum disorders (ASD) are pervasive neurodevelopmental disorders that affect an estimated 1 in 110 individuals. Although there is a strong genetic component associated with these disorders, this review focuses on the multifactorial nature of ASD and how different genome-wide (genomic) approaches contribute to our understanding of autism.…
Descriptors: Genetics, Pervasive Developmental Disorders, Autism, Children
A Genome-Wide Association Study of Autism Incorporating Autism Diagnostic Interview-Revised, Autism Diagnostic Observation Schedule, and Social Responsiveness Scale
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Connolly, John J.; Glessner, Joseph T.; Hakonarson, Hakon – Child Development, 2013
Efforts to understand the causes of autism spectrum disorders (ASDs) have been hampered by genetic complexity and heterogeneity among individuals. One strategy for reducing complexity is to target endophenotypes, simpler biologically based measures that may involve fewer genes and constitute a more homogenous sample. A genome-wide association…
Descriptors: Autism, Pervasive Developmental Disorders, Genetics, Genetic Disorders
The Utility of Chromosomal Microarray Analysis in Developmental and Behavioral Pediatrics
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Beaudet, Arthur L. – Child Development, 2013
Chromosomal microarray analysis (CMA) has emerged as a powerful new tool to identify genomic abnormalities associated with a wide range of developmental disabilities including congenital malformations, cognitive impairment, and behavioral abnormalities. CMA includes array comparative genomic hybridization (CGH) and single nucleotide polymorphism…
Descriptors: Genetics, Genetic Disorders, Developmental Disabilities, Identification