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Abel, Emily A.; Schwichtenberg, A. J.; Mannin, Olivia R.; Marceau, Kristine – Journal of Autism and Developmental Disorders, 2020
Sleep disorders (SD) are common in autism spectrum disorder (ASD), yet relatively little is known about the potential genetic mechanisms involved in SD and ASD comorbidity. The current study begins to fill this gap with a gene enrichment study that (1) identifies risk genes that contribute to both SD and ASD which implicate circadian entrainment,…
Descriptors: Genetics, Sleep, Autism, Pervasive Developmental Disorders
Zuniga-Kennedy, Miranda; Davoren, Micah; Shuffrey, Lauren C.; Luna, Ruth Ann; Savidge, Tor; Prasad, Vinay; Anderson, George M.; Veenstra-VanderWeele, Jeremy; Williams, Kent C. – Journal of Autism and Developmental Disorders, 2022
Hyperserotonemia, or elevated levels of whole blood serotonin (WB5-HT), was the first biomarker linked to autism spectrum disorder (ASD). Despite numerous studies investigating the etiology of hyperserotonemia, results have been inconsistent. Recent findings suggest a relationship between the immune system and hyperserotonemia. The current study…
Descriptors: Children, Autism, Pervasive Developmental Disorders, Biochemistry
Shindler, A. E.; Hill-Yardin, E. L.; Petrovski, S.; Bishop, N.; Franks, A. E. – Journal of Autism and Developmental Disorders, 2020
This study investigated genetic biomarkers for gastrointestinal dysfunction symptoms in order to provide further information on the genetic risk for GI dysfunction associated with autism. The single nucleotide polymorphisms of sixty participants with autism and/or gastrointestinal dysfunction were analyzed. The autism group had a moderate…
Descriptors: Genetics, Symptoms (Individual Disorders), Physiology, Risk
Cord and Early Childhood Plasma Adiponectin Levels and Autism Risk: A Prospective Birth Cohort Study
Raghavan, Ramkripa; Fallin, M. Daniele; Hong, Xiumei; Wang, Guoying; Ji, Yuelong; Stuart, Elizabeth A.; Paige, David; Wang, Xiaobin – Journal of Autism and Developmental Disorders, 2019
Emerging research suggests that adiponectin, a cytokine produced by adipose tissue, may be implicated in ASD. In this prospective birth cohort study (n = 847), we assessed the association between cord, early childhood plasma adiponectin and the risk of developing ASD. ASD was defined based on ICD codes of physician diagnosis. Cord adiponectin…
Descriptors: Autism, Pervasive Developmental Disorders, Risk, Physiology
Siu, Michelle T.; Goodman, Sarah J.; Yellan, Isaac; Butcher, Darci T.; Jangjoo, Maryam; Grafodatskaya, Daria; Rajendram, Rageen; Lou, Youliang; Zhang, Rujun; Zhao, Chunhua; Nicolson, Rob; Georgiades, Stelios; Szatmari, Peter; Scherer, Stephen W.; Roberts, Wendy; Anagnostou, Evdokia; Weksberg, Rosanna – Journal of Autism and Developmental Disorders, 2021
Many neurodevelopmental disorders (NDDs) share common learning and behavioural impairments, as well as features such as dysregulation of the oxytocin hormone. Here, we examined DNA methylation (DNAm) in the 1st intron of the oxytocin receptor gene, "OXTR," in patients with autism spectrum (ASD), attention deficit and hyperactivity (ADHD)…
Descriptors: Genetics, Autism, Pervasive Developmental Disorders, Biochemistry
Carvalho Pereira, Andreia; Violante, Inês R.; Mouga, Susana; Oliveira, Guiomar; Castelo-Branco, Miguel – Journal of Autism and Developmental Disorders, 2018
The nature of neurochemical changes in autism spectrum disorder (ASD) remains controversial. We compared medial prefrontal cortex (mPFC) neurochemistry of twenty high-functioning children and adolescents with ASD without associated comorbidities and fourteen controls. We observed reduced total N-acetylaspartate (tNAA) and total creatine, increased…
Descriptors: Autism, Pervasive Developmental Disorders, Adolescents, Brain Hemisphere Functions
Saghazadeh, Amene; Rezaei, Nima – Journal of Autism and Developmental Disorders, 2017
Brain-derived neurotrophic factor (BDNF) plays an important role in activity-dependent synaptic plasticity. Altered blood BDNF levels have been frequently identified in people with autism spectrum disorders (ASD). There are however wide discrepancies in the evidence. Therefore, we performed the present systematic review and meta-analysis aimed at…
Descriptors: Meta Analysis, Brain Hemisphere Functions, Patients, Control Groups
Rossignol, Daniel A.; Frye, Richard E. – Developmental Medicine & Child Neurology, 2011
Aim: The aim of this study was to investigate melatonin-related findings in autism spectrum disorders (ASD), including autistic disorder, Asperger syndrome, Rett syndrome, and pervasive developmental disorders, not otherwise specified. Method: Comprehensive searches were conducted in the PubMed, Google Scholar, CINAHL, EMBASE, Scopus, and ERIC…
Descriptors: Autism, Effect Size, Correlation, Pervasive Developmental Disorders
Mouridsen, Svend Erik; Rich, Bente; Isager, Torben – Developmental Medicine & Child Neurology, 2010
Aim: To study the sex ratio (proportion of males) in siblings of individuals diagnosed with autism spectrum disorders (ASDs) as children. Method: In the current study, we extended previous studies dealing with the androgen theory of autism and examined sex ratios in the siblings of 326 individuals with ASD (245 males, 81 females) who had been…
Descriptors: Siblings, Females, Autism, Psychiatry