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Direct linkThurman, Angela John; Swinehart, Stephanie Summers; Klusek, Jessica; Roberts, Jane E.; Bullard, Lauren; Marzan, Jocelyn Christina B.; Brown, W. Ted; Abbeduto, Leonard – American Journal on Intellectual and Developmental Disabilities, 2022
By adulthood, most males with fragile X syndrome (FXS) require support to navigate day-to-day settings. The present study cross-sectionally: (1) characterized the profile of daily living skills in males with FXS and (2) examined associated participant characteristics (i.e., fragile X mental retardation protein [FMRP] expression, nonverbal…
Descriptors: Genetic Disorders, Daily Living Skills, Males, Adolescents
Fielding-Gebhardt, Heather; Bredin-Oja, Shelley L.; Warren, Steven F. – American Journal on Intellectual and Developmental Disabilities, 2021
The development of an expressive language score for people with autism based on the ADOS-2 was recently reported by Mazurek et al. (2019). The current study examined the construct validity of the ADOS-2 expressive language score (ELS) in a sample of adolescents with fragile X syndrome (n = 45, 10 girls), a neurodevelopmental disorder with high…
Descriptors: Autism, Pervasive Developmental Disorders, Expressive Language, Genetic Disorders
Harrop, Clare; Dallman, Aaron R.; Lecavalier, Luc; Bodfish, James W.; Boyd, Brian A. – American Journal on Intellectual and Developmental Disabilities, 2021
Behavioral inflexibility (BI) has been highlighted to occur across genetic and neurodevelopmental disorders. This study characterized BI in two common neurogenetic conditions: Fragile X syndrome (FXS) and Down syndrome (DS). Caregivers of children with FXS (N = 56; with ASD = 28; FXS only = 28) and DS (N = 146) completed the Behavioral…
Descriptors: Down Syndrome, Genetic Disorders, Neurological Impairments, Developmental Disabilities
Klusek, Jessica; Martin, Gary E.; Losh, Molly – American Journal on Intellectual and Developmental Disabilities, 2013
This study tested the hypothesis that pragmatic (i.e., social) language impairment is linked to arousal dysregulation in autism spectrum disorder (ASD) and fragile X syndrome (FXS). Forty boys with ASD, 39 with FXS, and 27 with typical development (TD), aged 4-15 years, participated. Boys with FXS were hyperaroused compared to boys with TD but did…
Descriptors: Physiology, Genetic Disorders, Pervasive Developmental Disorders, Autism
Chaidez, Virginia; Hansen, Robin L.; Hertz-Picciotto, Irva – Autism: The International Journal of Research and Practice, 2012
Objectives: To compare differences in autism between Hispanic and non-Hispanics. We also examined the relationship between multiple language exposure and language function and scores of children. Methods: The Childhood Autism Risks from Genetics and the Environment (CHARGE) study is an ongoing population-based case-control study with children…
Descriptors: Autism, Genetics, Receptive Language, Expressive Language
McDuffie, Andrea; Kover, Sara; Abbeduto, Leonard; Lewis, Pamela; Brown, Ted – American Journal on Intellectual and Developmental Disabilities, 2012
The authors examined receptive and expressive language profiles for a group of verbal male children and adolescents who had fragile X syndrome along with varying degrees of autism symptoms. A categorical approach for assigning autism diagnostic classification, based on the combined use of the Autism Diagnostic Interview--Revised and the Autism…
Descriptors: Receptive Language, Expressive Language, Language Skills, Profiles
Price, J.; Roberts, J.; Vandergrift, N.; Martin, G. – Journal of Intellectual Disability Research, 2007
Background: Fragile X syndrome (FXS) is the most common known inherited cause of intellectual disability, yet very few studies have explored the language comprehension skills of children with FXS. We examined the receptive vocabulary, grammatical morphology and syntax skills of boys with FXS (who were additionally classified as having autism,…
Descriptors: Morphology (Languages), Down Syndrome, Syntax, Sentences
Landa, Rebecca; Garrett-Mayer, Elizabeth – Journal of Child Psychology and Psychiatry, 2006
Background: Autism is rarely diagnosed before three years of age despite evidence suggesting prenatal abnormalities in neurobiological processes. Little is known about when or how development becomes disrupted in the first two years of life in autism. Such information is needed to facilitate early detection and early intervention. Methods: This…
Descriptors: Siblings, Early Intervention, Medical Evaluation, Autism
