Much of Western thought has been informed by an ontology of being and a desire to uncover or establish universal truths and principles. This tradition has catalyzed our propensity to see change and difference through the lens of crisis. With this frame in mind, I invite readers to reconsider our relationship to change and difference by discussing the meditations of Heraclitus, Marcus Aurelius, and Friedrich Nietzsche. I conclude by discussing an approach to life, which I call agential equanimity, that embraces change--including COVID, climate change, and inequality as it decenters our anthropomorphic worldview and reminds us that we humans are fully within nature.