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Direct linkReumann, Rebecca; Vierk, Ricardo; Zhou, Lepu; Gries, Frederice; Kraus, Vanessa; Mienert, Julia; Romswinkel, Eva; Morellini, Fabio; Ferrer, Isidre; Nicolini, Chiara; Fahnestock, Margaret; Rune, Gabriele; Glatzel, Markus; Galliciotti, Giovanna – Learning & Memory, 2017
The serine protease inhibitor neuroserpin regulates the activity of tissue-type plasminogen activator (tPA) in the nervous system. Neuroserpin expression is particularly prominent at late stages of neuronal development in most regions of the central nervous system (CNS), whereas it is restricted to regions related to learning and memory in the…
Descriptors: Neurology, Metabolism, Memory, Learning
Zhang, Wen-Hua; Williams, Ziv M. – Learning & Memory, 2015
Once a memory has formed, it is thought to undergo a gradual transition within the brain from short- to long-term storage. This putative process, however, also poses a unique problem to the memory system in that the same learned items must also be retrieved across broadly varying time scales. Here, we find that neurons in the ventrolateral…
Descriptors: Memory, Brain Hemisphere Functions, Animals, Intervals
Luo, Minmin; Zhou, Jingfeng; Liu, Zhixiang – Learning & Memory, 2015
The dorsal raphe nucleus (DRN) represents one of the most sensitive reward sites in the brain. However, the exact relationship between DRN neuronal activity and reward signaling has been elusive. In this review, we will summarize anatomical, pharmacological, optogenetics, and electrophysiological studies on the functions and circuit mechanisms of…
Descriptors: Brain Hemisphere Functions, Neurological Organization, Rewards, Anatomy
Koffarnus, Mikhail N.; Jarmolowicz, David P.; Mueller, E. Terry; Bickel, Warren K. – Journal of the Experimental Analysis of Behavior, 2013
Excessively devaluing delayed reinforcers co-occurs with a wide variety of clinical conditions such as drug dependence, obesity, and excessive gambling. If excessive delay discounting is a trans-disease process that underlies the choice behavior leading to these and other negative health conditions, efforts to change an individual's discount rate…
Descriptors: Delay of Gratification, Conceptual Tempo, Reinforcement, Therapy
Parker, Karen J.; Buckmaster, Christine L.; Lindley, Steven E.; Schatzberg, Alan F.; Lyons, David M. – International Journal of Behavioral Development, 2012
Monkeys exposed to stress inoculation protocols early in life subsequently exhibit diminished neurobiological responses to moderate psychological stressors and enhanced cognitive control of behavior during juvenile development compared to non-inoculated monkeys. The present experiments extended these findings and revealed that stress inoculated…
Descriptors: Stress Management, Physiology, Animals, Brain Hemisphere Functions
Segalowitz, S. J.; Davies, Patricia L. – Brain and Cognition, 2004
Tracking the functional development of specific regions of the prefrontal cortex in children using event-related potentials (ERPs) is challenging for both technical and conceptual reasons. In this paper we outline our strategy for studying frontal lobe development and present preliminary results from children aged 7-17 years and young adults using…
Descriptors: Physiology, Children, Maturity (Individuals), Individual Development
