This is the first of a series of three instructor manuals in x-ray science and engineering and is produced as part of a project of Oregon State University's Bureau of Radiological Health. This manual, and the two companion manuals, have been tested in courses at Oregon State. These materials have been designed to serve as models for teaching and training programs in x-ray science and engineering. The manuals contain lecture outlines, laboratory exercises, and examinations. References, required equipment, and materials are listed. Each lecture and each laboratory exercise is essentially self-contained to permit other schools to select material on the basis of available time and equipment and the objectives of their instructional program. Equipment has been identified by model and manufacturer, but instructors may substitute equivalent equipment or alter course content to make use of available equipment. Fourteen lectures and eight laboratory exercises are presented in the first manual. Among other topics, these deal with the interaction of x-rays with matter, x-ray detection, chemical dosimetry, and correlation of exposure and absorbed dose. (PEB)