Drug repurposing refers to the process of discovering new therapeutic uses for existing medicines. Compared to traditional drug discovery, drug repurposing is attractive for its speed, cost, and reduced risk of failure. However, existing approaches for drug repurposing involve complex, computationally-intensive analytical methods that are not…

Longitudinal data structures are frequently encountered in a variety of disciplines in the social and behavioral sciences. Growth curve modeling offers a highly extensible framework that allows for the exploration of rich hypotheses. However, owing to the presence of interrelated sources of potential data-model misfit at multiple levels, the…

We consider two-level models where a continuous response R and continuous covariates C are assumed missing at random. Inferences based on maximum likelihood or Bayes are routinely made by estimating their joint normal distribution from observed data R[subscript obs] and C[subscript obs]. However, if the model for R given C includes random…

Past research indicates that individuals respond adaptively to contextual factors in multiattribute choice tasks. Yet it remains unclear how this adaptation is cognitively governed. In this article, empirically testable implementations of two prominent competing theoretical frameworks are developed and compared across two multiattribute choice…

A strategy to facilitate understanding of spatial randomness is described, using student activities developed in sequence: looking at spatial patterns, simulating approximate spatial randomness using a grid of equally-likely squares, using binomial probabilities for approximations and predictions and then comparing with given Poisson…

Metrics including Cohen's kappa, precision, recall, and F[subscript 1] are common measures of performance for models of discrete student states, such as a student's affect or behaviour. This study examined discrete model metrics for previously published student model examples to identify situations where metrics provided differing perspectives on…

Artificial intelligence-enabled adaptive learning systems (AI-ALS) are increasingly being deployed in education to enhance the learning needs of students. However, educational stakeholders are required by policy-makers to conduct an independent evaluation of the AI-ALS using a small sample size in a pilot study, before that AI-ALS can be approved…

We estimate the percentage of eligible students who do not take up their federal need-based student financial aid entitlements in a microsimulation model for the German Socio-Economic Panel Study 2002--2013. We find that about 40% of the eligible low-income students do not take up their entitlements. Non-take-up is inversely and rather…

In order to increase students' awareness for and comfort with mathematical modeling of biological processes, and increase their understanding of diffusion, the following lab was developed for use in 100-level, majors/non-majors biology and neuroscience courses. The activity begins with generation of a data set that uses coin-flips to replicate…

Readers tend to skip words, particularly when they are short, frequent, or predictable. Angele and Rayner (2013) recently reported that readers are often unable to detect syntactic anomalies in parafoveal vision. In the present study, we manipulated target word predictability to assess whether contextual constraint modulates…

Modeling student knowledge is a fundamental task of an intelligent tutoring system. A popular approach for modeling the acquisition of knowledge is Bayesian Knowledge Tracing (BKT). Various extensions to the original BKT model have been proposed, among them two novel models that unify BKT and Item Response Theory (IRT). Latent Factor Knowledge…

This simulation study compared the utility of various discrepancy measures within a posterior predictive model checking (PPMC) framework for detecting different types of data-model misfit in multidimensional Bayesian network (BN) models. The investigated conditions were motivated by an applied research program utilizing an operational complex…

The current Situational Space Awareness (SSA) is faced with a huge task of tracking the increasing number of space objects. The tracking of space objects requires frequent and accurate monitoring for orbit maintenance and collision avoidance using methods for statistical orbit determination. Statistical orbit determination enables us to obtain…

Person-fit assessment may help the researcher to obtain additional information regarding the answering behavior of persons. Although several researchers examined person fit, there is a lack of research on person-fit assessment for mixed-format tests. In this article, the lz statistic and the ?2 statistic, both of which have been used for tests…

Tossing a fair coin 1000 times can have an unexpected result. In the activities presented here, players keep track of the accumulated total for heads and tails after each toss, noting which player is in the lead or whether the players are tied. The winner is the player who was in the lead for the higher number of turns over the course of the game.…