Stress is a health-compromising issue for undergraduate students that has only seemed to worsen during the COVID-19 pandemic. While most universities offer traditional medicinal treatments, prior research has suggested that some students prefer to utilize complementary and alternative medicine (CAM) to cope with stress and illness. Given the growing popularity of CAM in the undergraduate population, the current study aimed to better understand the patterns underlying CAM usage during the COVID-19 pandemic. In our study, we examined whether individual difference variables such as the Big Five personality traits and perceived health locus of control as well as constructs like perceived stress predict CAM usage in undergraduates. Implications as well as suggestions for future studies are discussed.