This study explored the impact of presence of meaning and search for meaning on career adaptability among college students, as well as the mediating role of professional identity. Using a convenience sampling method, 435 college students from Guangxi participated. The findings revealed that both presence of meaning and search for meaning positively influence career adaptability, with professional identity acting as a mediator. This research enhances understanding of career adaptability's determinants and offers insights for improvement. The study suggests that schools can support students by offering relevant courses to help them find life's meaning, fostering a strong professional identity, and positive values to boost career adaptability.