The Career and Technical Education (CTE) playbook series has explored strategies and processes states can use to strengthen CTE program quality and provide students with pathways to postsecondary credentialing and middle- and higher-wage career opportunities. This fifth playbook in the series addresses the final set of steps for strengthening state CTE programs: developing CTE programs of study that align to postsecondary and in-demand career opportunities. These steps include: (1) Establish the core elements of high-quality programs of study and a process for alignment; (2) Align CTE programs of study to the state's priorities for program quality, alignment and desired outcomes; and (3) Implement fully-aligned programs of study and an ongoing evaluation of results. By this point, policymakers have established priorities (see playbook 1, ED609912), convened partners (see playbook 2, ED609958), and analyzed the gaps and opportunities in their existing programs (see playbooks 3 and 4, ED609960 and ED609961). Now the hard--but exciting--work of making transformative programmatic changes and improvements begins!