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Direct linkSharon Hardiman; Rory Cousins; Aisling Ryan; Maria Kennedy; Leigh Hagan; Flavia H. Santos – Journal of Applied Research in Intellectual Disabilities, 2025
Background: Most adults with Down syndrome develop Alzheimer's disease (AD) pathology in their 30s, yet research into cognitive health programmes for this group remains limited. Method: A mixed-methods feasibility randomised control trial (RCT) evaluated an adapted, manualised group-based cognitive stimulation therapy (CST) programme for adults…
Descriptors: Adults, Down Syndrome, Alzheimers Disease, Cognitive Ability
Verduzco, Luis; van Dyck, Christopher H.; Arnsten, Amy F. T.; Ramos, Brian P.; Stark, David – Learning & Memory, 2006
The working-memory functions of the prefrontal cortex (PFC) are improved by stimulation of postsynaptic, [alpha]2A-adrenoceptors, especially in aged animals with PFC cognitive deficits. Thus, the [alpha]2A-adrenoceptor agonist, guanfacine, greatly improves working-memory performance in monkeys and rats following systemic administration or…
Descriptors: Behavioral Science Research, Memory, Stimulation, Program Effectiveness
