Course-based undergraduate experiences (CUREs) have been employed to enhance students' content knowledge, self-efficacy, science identity, and enrollment in postgraduate programs. In this study, we used it as a science communication skills enhancement tool. The CURE-Comm Framework was implemented to integrate science communication into a CURE in an upper-level microbiology course. The results showed significant improvement in students' ability to communicate scientific information to diverse audiences, research comprehension, ethics, and practical skills. Pre/post-course surveys indicated no significant increase in communication skills toward non-science audiences, researcher identity, confidence and independence, and equity, diversity, and inclusion awareness. However, analysis of in-class and podcast presentations and interviews revealed important gains in all areas. This study highlights the utility of the CURE-Comm Framework in enhancing science communication skills, particularly through data analysis, literature exposure, multiple writing and oral presentation opportunities, and constructive feedback.