Neuroleptic malignant syndrome, an uncommon but potentially lethal complication of antipsychotic medication, is reviewed, including analysis of 29 cases in which the condition appeared in individuals with mental retardation. Recommendations about reducing morbidity and mortality in this population are offered. (Author/DB)

The efficacy of the atypical antipsychotic risperidone was evaluated in the treatment of aberrant behavior (e.g., aggression, self-injury) in 20 individuals with developmental disabilities. The study, a double-blind crossover design, identified 50 percent of participants as responders. Naturalistic observations of five participants showed that…

Severely and profoundly mentally retarded institutionalized residents (N=74) who received lithium carbonate for behavior disorders were followed in a 10-year retrospective study. Thirty-one subjects demonstrated a sustained major reduction or elimination of behavioral symptoms. Lithium responders were likely to be older and to present symptoms of…

Distributions of psychiatric classifications among 42,479 persons with mental retardation were reviewed to determine relative rates of disorders for persons with both mental retardation and mental disorder. Analyses indicated that rates of reported schizophrenic and psychotic disorders were generally higher than expected relative to rates of other…

Sixty-eight community-dwelling individuals with mental retardation and mental illness were discontinued from neuroleptics. Those with a psychotic disorder were significantly more likely to be restarted on neuroleptics at 3 months and 12 months. Not having a history of delusions was significantly associated with remaining neuroleptic-free at 3…

Records covering a five-year period of adults with mental retardation in a residential program were reviewed to determine differences in antipsychotic dosages over time. Findings suggest that individuals with mental retardation who do not have psychoses are a suitable group for dosage reduction and that use of alternative medications facilitates…

Information on admission to psychiatric inpatient units is lacking from the literature on contemporary services for people with intellectual disability and mental health needs. Here we report on predictors of admission for a cohort of 752 adults from this population living in community settings; 83 were admitted. We also report on two subsamples…