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A Protocol for Sedation Free MRI and PET Imaging in Adults with Autism Spectrum Disorder
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Smith, C. J.; Bhanot, A.; Norman, E.; Mullett, J. E.; Bilbo, S. D.; McDougle, C. J.; Zürcher, N. R.; Hooker, J. M. – Journal of Autism and Developmental Disorders, 2019
Imaging technologies such as positron emission tomography (PET) and magnetic resonance imaging (MRI) present unparalleled opportunities to investigate the neural basis of autism spectrum disorder (ASD). However, challenges such as deficits in social interaction, anxiety around new experiences, impaired language abilities, and hypersensitivity to…
Descriptors: Adults, Autism, Pervasive Developmental Disorders, Training Methods
Bone Mass in Boys with Autism Spectrum Disorder
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Calarge, Chadi A.; Schlechte, Janet A. – Journal of Autism and Developmental Disorders, 2017
To examine bone mass in children and adolescents with autism spectrum disorders (ASD). Risperidone-treated 5 to 17 year-old males underwent anthropometric and bone measurements, using dual-energy X-ray absorptiometry and peripheral quantitative computed tomography. Multivariable linear regression analysis models examined whether skeletal outcomes…
Descriptors: Autism, Pervasive Developmental Disorders, Males, Children
Bone Mineral Density in Boys Diagnosed with Autism Spectrum Disorder: A Case-Control Study
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Barnhill, Kelly; Ramirez, Lucas; Gutierrez, Alan; Richardson, Wendy; Marti, C. Nathan; Potts, Amy; Shearer, Rebeca; Schutte, Claire; Hewitson, Laura – Journal of Autism and Developmental Disorders, 2017
This study compared bone mineral density (BMD) of the spine obtained by dual-energy X-ray absorptiometry (DEXA), nutritional status, biochemical markers, and gastrointestinal (GI) symptoms in 4-8 year old boys with Autism Spectrum Disorder (ASD) with a group of age-matched, healthy boys without ASD. Boys with ASD had significantly lower spine BMD…
Descriptors: Males, Pervasive Developmental Disorders, Autism, Case Studies
Bone Density in Adolescents and Young Adults with Autism Spectrum Disorders
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Ekhlaspour, Laya; Baskaran, Charumathi; Campoverde, Karen Joanie; Sokoloff, Natalia Cano; Neumeyer, Ann M.; Misra, Madhusmita – Journal of Autism and Developmental Disorders, 2016
Patients with autism spectrum disorder (ASD) are at increased risk for fracture, and peri-pubertal boys with ASD have lower bone mineral density (BMD) than controls. Data are lacking regarding BMD in older adolescents with ASD. We compared BMD using dual-energy X-ray absorptiometry in 9 adolescents/young adults with ASD against 9 typically…
Descriptors: Autism, Pervasive Developmental Disorders, Human Body, At Risk Persons
Normal Rates of Neuroradiological Findings in Children with High Functioning Autism
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Vasa, Roma A.; Ranta, Marin; Huisman, Thierry A. G. M.; Pinto, Pedro S.; Tillman, Rachael M.; Mostofsky, Stewart H. – Journal of Autism and Developmental Disorders, 2012
Magnetic resonance imaging (MRI) has been used to analyze highly specific volumetric and morphological features of the brains of individuals with autism spectrum disorder (ASD). To date, there are few comprehensive studies examining the prevalence of neuroradiologic findings seen on routine MRI scans in children with ASD. This study examined the…
Descriptors: Attention Deficit Hyperactivity Disorder, Incidence, Autism, Neurological Impairments
Offering to Share: How to Put Heads Together in Autism Neuroimaging
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Belmonte, Matthew K.; Mazziotta, John C.; Minshew, Nancy J.; Evans, Alan C.; Courchesne, Eric; Dager, Stephen R.; Bookheimer, Susan Y.; Aylward, Elizabeth H.; Amaral, David G.; Cantor, Rita M.; Chugani, Diane C.; Dale, Anders M.; Davatzikos, Christos; Gerig, Guido; Herbert, Martha R.; Lainhart, Janet E.; Murphy, Declan G.; Piven, Joseph; Reiss, Allan L.; Schultz, Robert T.; Zeffiro, Thomas A.; Levi-Pearl, Susan; Lajonchere, Clara; Colamarino, Sophia A. – Journal of Autism and Developmental Disorders, 2008
Data sharing in autism neuroimaging presents scientific, technical, and social obstacles. We outline the desiderata for a data-sharing scheme that combines imaging with other measures of phenotype and with genetics, defines requirements for comparability of derived data and recommendations for raw data, outlines a core protocol including…
Descriptors: Autism, Genetics, Measurement Techniques, Data Analysis
Development of the Brainstem and Cerebellum in Autistic Patients.
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Hashimoto, Toshiaki; And Others – Journal of Autism and Developmental Disorders, 1995
This study of 102 individuals with autism found that the brainstem and cerebellum increased in size with age but were significantly smaller in autistic patients than in controls. Analysis of the speed of development suggests that brainstem and vermian abnormalities in autism were due to an early insult and hypoplasia rather than to progressive…
Descriptors: Anatomy, Autism, Child Development, Clinical Diagnosis
New Evidence of Cerebellar and Brainstem Hypoplasia in Autistic Infants, Children and Adolescents: The MR Imaging Study by Hashimoto and Colleagues.
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Courchesne, Eric – Journal of Autism and Developmental Disorders, 1995
In a study by Toshiaki Hashimoto and colleagues (EC 611 142), 10 infants with developmental delay, poor eye contact, and poor facial expression underwent magnetic resonance brain imaging and were later diagnosed with autism. This offered direct evidence of abnormality of the cerebellar vermis and the brainstem at the beginning stages of behavioral…
Descriptors: Age, Anatomy, Autism, Child Development