Cancer survivors experience both physical and cognitive changes after treatment that can impact their vocational well-being should they decide to return to work. In this article, we explore the ways in which career counselling interventions can address the challenges faced by cancer survivors as they re-enter the workforce. Four major career-related issues are outlined: physical functioning abilities, changes in cognitive functioning, changing perspectives and support. These issues are addressed using life-career transition and career counselling theories. Theory-informed helping strategies are considered for career counselling cancer survivors as they improve their vocational life and other aspects of personal well-being.