We consider a class of multiple-group individually-randomized group trials (IRGTs) that introduces a (partially) cross-classified structure in the treatment condition (only). The novel feature of this design is that the nature of the treatment induces a clustering structure that involves two or more non-nested groups among individuals in the…

Cluster randomized trials (CRTs) are commonly used to evaluate the causal effects of educational interventions, where the entire clusters (e.g., schools) are randomly assigned to treatment or control conditions. This study introduces statistical methods for designing and analyzing two-level (e.g., students nested within schools) and three-level…

The purpose of this dissertation is to develop principles and strategies for and identify limitations of multisite cluster randomized trials in the context of partially and fully nested designs. In the first study, I develop principles of estimation, sampling variability, and inference for studies that leverage multisite designs within the context…