In obsessive-compulsive disorder (OCD), functional behaviors such as checking that a door is locked become dysfunctional, maladaptive, and debilitating. However, it is currently unknown how aversive and appetitive motivations interact to produce functional and dysfunctional behavior in OCD. Here we show a double dissociation in the effects of…

Recent research in psychology, psychiatry and neuroscience has demonstrated reliable associations between temperament and individual differences in sensitivity and responsiveness to environmental cues and behavioral consequences. Temperament-influenced behavior patterns evident in infancy have also been found to predict behavioral tendencies in…