Electrophilic aromatic substitution (EAS) represents an important class of reactions taught in the undergraduate organic chemistry curriculum. The EAS reaction of benzene and its substituted derivatives is generally described as proceeding through a carbocation (arenium cation) intermediate, and the regiochemistry of the product is heavily…

Students often have no exposure to the incredible amount of genomic and proteomic data that is freely and easily accessible online. Becoming familiar with these resources, and seeing how they could be applied to a specific research question, is a prerequisite for students to apply them to their own scientific development. Many students have to…

Previous articles in "Primary Science" have presented a range of ways to teach electricity in engaging and informative ways (e.g. Buckley and Harvey, 2014; Chapman, 2014; Norman, 2014; CLEAPSS, 2016) and Frank Harris provides an interesting historical account of the development and use of batteries in "School Science Review"…

Computational chemistry techniques are used along with spectroscopy to characterize acetaminophen synthesized in an undergraduate chemistry laboratory experiment. The inclusion of electronic structure calculations to provide infrared and Raman spectra in the synthesis and characterization of acetaminophen connects over-the-counter medications with…

The activity presented in this article is part of a four-part module that centers earthquakes as a common phenomenon that students experience and introduces the idea of a resonant frequency. When the seismic waves from an earthquake encounter a building, the subsequent oscillating motion of the ground causes the building to move back and forth.…

The "Next Generation Science Standards" (NGSS) encourages educators to help kindergarteners formalize a big idea in physics: A push or pull can cause an object to begin moving, speed up, slow down, stop, or change the direction it is going (NGSS Lead States 2013). In this article, the authors share an exciting, classroom-tested…

Sanger sequencing, also known as dideoxy sequencing, is a widely used method for DNA sequencing, particularly for cloned plasmids and clinical samples. This technique requires a combination of essential biochemistry skills, such as a chain-termination reaction, gel electrophoresis, and fluorescence detection. Unfortunately, there is a lack of…

An inexpensive at-home quantitative analysis activity was developed for the determination of glucose in unknown samples using paper-based microfluidic devices. All of the materials and reagents for the activity fit in a small kit that was mailed to students. The only items students needed to supply were water and a smartphone. Microgram quantities…

It may be asserted that there is no more effective deterrent to crime than the certainty of detection. Equally true is that there is no surer way to establishing identity than by fingerprints. The detection of fingerprints at the scene of crime is therefore one of the most powerful tools available in casework investigations. However, if the crime…

The "Forty Electronic Challenges" is a "discovery learning" and socio-constructivist science activity that has become rather popular in Canada. The article recalls its emergence and development. It discusses its theoretical underpinnings and how it fits into the existing literature. It then gives educators all the guidelines…

Proteopedia (proteopedia.org) is an open resource to explore the structure--function relationship of proteins and other biomolecules. This guide provides practical advice on how to incorporate Proteopedia into teaching the structure and function of proteins and other biomolecules. For 11 activities, we discuss desired outcomes, setting…

Investigating stars can be difficult. The five-day unit presented in this article is designed for fifth graders to work toward Next Generation Science Standard (NGSS) performance expectation 5-ESS1-1, with each lesson lasting about 30 minutes. Students investigate the relationship between the brightness of light and distance, apply their…

The purpose of this article is to describe a modeling sequence about the digestive system. "What happens in your body when you have lactose intolerance?" is the initial question that will guide the activities. Students will build a 3D plaster cast of the digestive system as part of a modeling cycle through which they are expected to…

Kids are drawn to dolls and dump trucks, and crashing the two together might just be a child's favorite pastime. Who knew such a simple pleasure could serve as an accessible, compelling phenomenon for instigating investigations of force and motion. With a few inexpensive materials straight out of the toy box (literally, a doll, a dump truck, a…

This article demonstrates how the authors used a 5E lesson about food webs as a context to embed speaking and listening standards. This 5E lesson partially addresses 5-LS2-1 in the "Next Generation Science Standards" and focuses primarily on predator/prey relationships. Future lessons focus on decomposition and other relationships. To…