Structure--activity relationships are foundational concepts in biochemistry and drug design. Despite their importance, it can be difficult to create and execute laboratory activities that allow students to directly observe the interactions between small-molecule drugs and their biomolecular targets. Here, we report an activity that investigates…

Graduate teaching assistants (GTAs) often lead laboratory and tutorial sections in science, technology, engineering, and mathematics (STEM), especially at large, research-intensive universities. GTAs' performance as instructors can impact student learning experience as well as learning outcomes. In this study, we observed 11 chemistry GTAs and 11…

Changes in environmental conditions can have a profound impact on organismal processes. For aquatic organisms, changes in dissolved oxygen concentration can have major repercussions, notably for physiological processes that have high long-term energetic costs and are more likely to rely on aerobic metabolic pathways. Here we propose a simple…

This work documents the collaboration between the Physics department of the University of Calabria and some schools of the region in a project devoted to recovering disused instrumentation in school laboratories. The project has been conceived as a workplace experience for the students, i.e. a learning experience in a real work place. In Italy,…

An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as part of the Distributed Drug Discovery (D3) program. Students use solid-phase synthesis techniques to complete a three-step, combinatorial synthesis of six products, which are analyzed using LC-MS and NMR spectroscopy. This protocol is suitable for…

In this teaching laboratory, the students are directed in an exercise that involves designing and performing an experiment to determine estrogen's role in regulating delayed implantation (diapause) in female rats. To encourage active participation by the students, a discussion question is provided before the laboratory exercise in which each…

A versatile and portable apparatus was developed to demonstrate exciting visual displays of catalytic phenomena that introduce basic concepts in catalysis, renewable energy, and chemical safety, in order to pique scientific curiosity in a variety of audiences including middle and high school students, undergraduate and graduate students, and the…

Practicing chemists use models, diagrams, symbols, and figures to represent phenomena which cannot be detected by the human senses. Although research suggests that these external representations (ERs) can also be used to address the challenges that students have in learning chemistry, it is not clear how instructors' use of ERs aligns with their…

This study aims to examine students' reasoning based on the model in each laboratory work style and find the effect on scientific attitude and student activity. This study uses a quantitative approach with the experimental method. The study was conducted in three classes with different lab work styles. Arduino and sensors were used as a…

We describe a set of conceptual and hands-on activities based around understanding the dynamics of a Slinky that is hung vertically and released from rest. This Slinky drop experiment typically lasts a fraction of a second, but when observed in slow motion, one sees the Slinky compress from the top down while the bottom portion remains at…

The American Association for the Advancement of Science (AAAS) strongly recommends that "science be taught as science is practiced." This means that the teaching approach must be consistent with the nature of scientific inquiry. In this article, the authors describe how they added scientific inquiry to a large lecture-based physiology…

The concepts of protein purification are often taught in undergraduate biology and biochemistry lectures and reinforced during laboratory exercises; however, very few reported activities allow students to directly gain experience using modern protein purification instruments, such as Fast Protein Liquid Chromatography (FPLC). This laboratory…

A laboratory experiment is described that extracts the tetrapyrrolic teal-colored biliverdin IXa, as its dimethyl ester, from commercially available emu eggshells. The extraction of ~10 mg samples of biliverdin is simple and requires two 3 h lab periods: A two-step acid digestion and liquid-liquid extraction, followed by short silica gel flash…

Several studies have showed the subsistence, even in students enrolled in scientific degree courses, of spontaneous ideas regarding the motion of bodies that conflict with Newton's laws. One of the causes is related to the intuitive preconceptions that students have about the role of friction as a force. In fact, in real world novices do not…

The dramatic decrease in the cost of sequencing a human genome is leading to an era in which a wide range of students will benefit from having an understanding of human genetic variation. Since over 90% of sequence variation between humans is in the form of single nucleotide polymorphisms (SNPs), a laboratory exercise has been devised in order to…