This study was conducted in the laboratory and Metaverse environment with "Acids-Bases," a science subject related to the Metaverse, one of today's technologies. In line with the purpose of the research, the embedded design of the mixed research method, which combined quantitative and qualitative research methods, was used. The experimental design was used in the quantitative dimension of the research, and an achievement test was applied to the students consisting of the experimental and control groups as a pretest/post-test. In the qualitative dimension of the research, a semi-structured interview form was applied using the case design. The study group consisted of secondary school students studying in a public school. The sample consists of 20 students, ten experimental and ten controlled. The result of the study was that the effect of the traditional laboratory environment on academic achievement was higher than that of the virtual laboratory environment.