ERIC Number: EJ1442490
Record Type: Journal
Publication Date: 2023-Feb
Pages: 9
Abstractor: As Provided
ISBN: N/A
ISSN: ISSN-0021-9584
EISSN: EISSN-1938-1328
Available Date: N/A
Targeted Drug Delivery: Synthesis of Smart Nanocarriers for School Chemistry Education
Antonia Fruntke; Mira Behnke; Leanne M. Stafast; Tom Träder; Elisabeth Dietel; Antje Vollrath; Christine Weber; Ulrich S. Schubert; Timm Wilke
Journal of Chemical Education, v100 n2 p751-759 2023
This publication presents a series of experiments in the field of nanomedicine for high school chemistry education and student laboratories, developed as a collaborative project between chemistry didactics and chemical research. In this context, polymeric nanocarriers represent a promising approach for drug delivery, acting as "smart packaging material" to ensure transport to the desired location in the body and a targeted release. This offers the opportunity of a locally higher drug concentration while reducing the overall dose administered and minimizing side effects of the drugs. In this article, we illustrate how this attractive field of research can be linked to polymer chemistry as a classical school topic through the model of transfer research. In addition, we present three experiments where polymer nanocarriers are (1) synthesized and (2) loaded with a fluorescent model substance, which is (3) selectively released through the degradation of the polyester carrier via hydrolysis. All experiments can be performed with simple and harmless chemicals within a time frame of two school lessons.
Descriptors: Chemistry, Science Education, Synthesis, Science Experiments, Secondary School Science, Medicine, Science Laboratories, Student Projects, Scientific Concepts, Experiential Learning
Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Publication Type: Journal Articles; Reports - Descriptive
Education Level: Secondary Education
Audience: N/A
Language: English
Sponsor: N/A
Authoring Institution: N/A
Grant or Contract Numbers: N/A
Author Affiliations: N/A