Drug ototoxicity research has relied traditionally on animal models for the discovery and development of therapeutic interventions. More than 50 years of research, however, has delivered few--if any--successful clinical strategies for preventing or ameliorating the ototoxic effects of common pharmacological drugs such as aminoglycoside…

Post-retrieval interference with a memory has uncovered a phenomenon known to the field as reconsolidation. In this article, we will review the specific molecular mechanisms that have been implicated in reconsolidation. As a result of numerous studies over the past five years, it can now be said with a fair amount of certainty that reconsolidation…

An amusement park is a large physics laboratory, full of rotating and accelerated coordinate systems. The forces are experienced throughout the body and can be studied with simple equipment or with electronics depending on age and experience. In this paper, we propose adaptations of classical physics experiments for use on traditional rides.…

An uncomplicated organic synthesis experiment with modafinil that showcases a prevalent modern antinarcoleptic drug as an approach to inspire students to learn real-world relevance is presented. The synthesis and analysis of racemic 2-(diphenylmethyl-sulfinyl)acetamide, (plus or minus)-modafinil, is suitable as a midlevel undergraduate organic…

Low-efficiency solar cells for educational purposes can be simply made in school or home environments using wet-chemistry techniques and readily available chemicals of generally low toxicity. Instructions are given for making solar cells based on the heterojunctions Cu/Cu[subscript 2]O, Cu[subscript 2]O/ZnO and Cu[subscript 2]S/ZnO, together with…

This case was developed for a sophomore organic chemistry lab to illustrate how a combination of techniques is usually required in the identification of chemical compounds. It involves a murder mystery with a forensic twist: Two bodies have been recovered from two different lakes, but because of a mix-up at the morgue, the coroner is unable to…

A study combined 1D (one-dimensional) and 2D (two-dimensional) NMR spectroscopy to solve structural organic problems of three unknowns, which include 2-, 3-, and 4-heptanone. Results showed [to the first power]H NMR and [to the thirteenth power]C NMR signal assignments for 2- and 3-heptanone were more challenging than for 4-heptanone owing to the…

An alternative method that uses a simple apparatus to measure vapor pressure versus temperature in a closed system, in which the total pressure is the vapor pressure of the liquid sample, is described. The use of this apparatus gives students a more direct picture of vapor pressure than the isoteniscope method and results have generally been quite…

The application of Lewis concept that provides students opportunity to predict and understand reaction behavior and themes in introductory chemistry of structure-property relationships of atoms, ions, and molecules is narrated. The general sequence takes the student through atomic structural theory, electronic configuration, periodicity, chemical…

In this article, the authors describe the mechanics of They're M-e-e-elting!, an activity wherein middle school students can simulate glacial retreat in Antarctica. They're M-e-e-elting! allows students to melt glaciers, change the water level and salinity of the Southern Ocean, and examine alterations to the Antarctic food web--all without…

The near daily news reports on food-borne diseases caused by contaminated produce, dairy, or meats suggests to the public that the safety of the U.S. food supply is in jeopardy. These reports, as well as a general distrust in federal agencies due in part to mad cow disease and toxigenic forms of "E. coli" in ground beef, have resulted in an…

This work investigates the presence of Thought Experiments (TEs) which refer to the theory of relativity and to quantum mechanics in physics textbooks and in books popularizing physics theories. A further point of investigation is whether TEs--as presented in popular physics books--can be used as an introduction to familiarize secondary school…

The physics of sound is often studied in introductory physics class experiments involving a tube of resonating air. In typical setups, pistons control the length of a cylindrical space or a microphone is moved within a tube. While these activities are useful and can be made very quantitative, they don't directly demonstrate the sounds that are…

A laboratory exercise is presented in which students determine where metabolic heat is primarily generated in blooming eastern skunk cabbage ("Symplocarpus foetidus") plants. Students consider how color, shape, and orientation of spathes, and stage of flower maturation, may affect metabolic heat production and retention of both metabolic and solar…

This field exercise examines the feeding preferences of Gray Squirrels ("Sciurus carolinensis"). Students present squirrels with a variety of food types in a cafeteria-style arrangement in order to test hypotheses about foraging preferences. This exercise, which is appropriate for introductory biology, ecology, and animal behavior classes, is…