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Naoto Shirasu; Shin'ichiro Yasunaga – Biochemistry and Molecular Biology Education, 2024
Here, we propose a laboratory exercise to quickly determine single nucleotide polymorphisms (SNPs) in human "alcohol dehydrogenase 1B (ADH1B)" and "aldehyde dehydrogenase 2 (ALDH2)" genes involved in alcohol metabolism. In this exercise, two different genotyping methods based on polymerase chain reaction (PCR), namely…
Descriptors: Genetics, Biochemistry, Students, Science Instruction
Tiantian Cheng; Lingzhen Cao; Meng Zou – American Biology Teacher, 2024
The central dogma of molecular biology describes the transfer of genetic information from nucleic acids to proteins and stipulates that the system cannot work in the reverse direction. As a fundamental principle in biology, the dogma is as influential as it is controversial. Some commentators have debated the central dogma's empirical accuracy…
Descriptors: Biology, Genetics, Science Instruction, Physiology
Hannah K. Parker; Beth Zizzamia; Julie A. Pollock – Journal of Chemical Education, 2025
In a typical undergraduate biochemistry course, two main educational objectives include (1) understanding and applying how genetic mutations can influence protein structure and function, and (2) examining metabolic pathways of biomolecules to study cellular storage and fuel. Many times, these topics can seem disparate to students; therefore, we…
Descriptors: Undergraduate Students, College Science, Science Instruction, Biochemistry
Singh, Anoushka; Miller, Ryan C.; Archuleta, Stephen R.; Kugel, Jennifer F. – Biochemistry and Molecular Biology Education, 2023
Transcription is the critical first step in expressing a gene, during which an RNA polymerase (RNAP) synthesizes an RNA copy of one strand of the DNA that encodes a gene. Here we describe a laboratory experiment that uses a single assay to probe two important steps in transcription: (1) RNAP binding to DNA, and (2) the transcriptional activity of…
Descriptors: Molecular Biology, Science Instruction, Genetics, Teaching Methods
Kylie Light; Jordan Brooks; Yun-Seok Choi – Journal of Chemical Education, 2023
Sanger sequencing, also known as dideoxy sequencing, is a widely used method for DNA sequencing, particularly for cloned plasmids and clinical samples. This technique requires a combination of essential biochemistry skills, such as a chain-termination reaction, gel electrophoresis, and fluorescence detection. Unfortunately, there is a lack of…
Descriptors: Genetics, Biochemistry, Science Instruction, Science Activities
Stephanie A. Carr; Stephanie L. Mathews; Justin A. Pruneski; Nikolas M. Stasulli – Journal of Microbiology & Biology Education, 2024
In this article, we describe curricular materials developed to engage undergraduate students in evolutionary thinking around antibiotic resistance using the MEGA-plate experiment (Microbial Evolution and Growth Arena). This elegant and visual experiment, developed by the Kishony Lab, shows the development of antibiotic resistance on the timescale…
Descriptors: Biochemistry, Science Instruction, Laboratory Experiments, Drug Therapy
Sousa, Cristina – American Biology Teacher, 2021
The origin of life is one of the most interesting and challenging questions in biology. This article discusses relevant contemporary theories and hypotheses about the origin of life, recent scientific evidence supporting them, and the main contributions of several scientists of different nationalities and specialties in different disciplines. Also…
Descriptors: Biology, Science Instruction, Cytology, Evolution
Keira D. Naff; Jeri L. Tyler; Dima H. Hamza; Jonathan D. White – Journal of Chemical Education, 2023
Structure--activity relationships are foundational concepts in biochemistry and drug design. Despite their importance, it can be difficult to create and execute laboratory activities that allow students to directly observe the interactions between small-molecule drugs and their biomolecular targets. Here, we report an activity that investigates…
Descriptors: Genetics, Undergraduate Students, Undergraduate Study, College Science
Yan, Jingmin; Chen, Jiangao; Mao, Xuhu; Li, Qian – Biochemistry and Molecular Biology Education, 2023
As a universal and extensively adopted technique, enzyme-linked immunosorbent assay (ELISA) can be used to detect and quantify small molecules in many applications both clinical and analytical. However, generally, students experiment mechanically using commercial ELISA kits according to the instructions and eventually produce a standard curve to…
Descriptors: Undergraduate Students, Science Instruction, Biotechnology, Biochemistry
Andrew Phillips; Anusha Srinivas; Ilina Prentoska; Margaret O'Dea; Matthew Kustrup; Sarah Hurley; Savannah Bruno; Vy Nguyen; Pin-Kuang Lai – Biochemistry and Molecular Biology Education, 2024
Teaching chemistry and biology students about biologics design remains challenging despite its increasing importance in pharmaceutical development. Monoclonal antibodies, commonly called mAbs, are the most popular biologics. They have been developed into drugs to treat various diseases in the past decades. Multiple challenges exist for designing…
Descriptors: Teaching Methods, Biochemistry, Science Instruction, Computer Software
Mahaffey, Angela L. – Biochemistry and Molecular Biology Education, 2020
DNA analysis is a common diagnostic tool in healthcare: ranging from microbial typing (e.g. DNA strands of viral, bacterial and even fungal pathogens), oncological screen (e.g. Breast cancer detection via DNA analysis of any BRCA gene mutations), genetic amniocentesis test (a medical technique used in determining chromosomal conditions such as…
Descriptors: Genetics, Science Instruction, Clinical Diagnosis, Genetic Disorders
Crane, Julia; Page, Shallee T. – Biochemistry and Molecular Biology Education, 2022
We present a course-embedded undergraduate research module that involves real-time polymerase chain reaction testing for the presence of SARS-CoV-2 in environmental samples. A positive control RNA was constructed and two RNA extraction methods were compared and a range of primers were available to compare. Using a combination of published…
Descriptors: Undergraduate Students, College Science, Science Instruction, Scientific Research
Suárez Casanova, Víctor Manuel; Shumskaya, Maria – Biochemistry and Molecular Biology Education, 2021
DNA structure has been leveraged in a variety of facets that allow scientists to perform a range of assays, including ones for identification of species, establishing evolutionary relationships between taxa, or even identifying individuals. Here, we present a DNA barcoding method as practical, hands-on approach that connects several experimental…
Descriptors: Genetics, Biochemistry, Science Instruction, Molecular Biology
Zeke T. Spooner; Angela M. Encerrado-Manriquez; Tina T. Truong; Sascha C. T. Nicklisch – Biochemistry and Molecular Biology Education, 2024
We created a 2-week, dual-module summer course introducing high school students to environmental toxicology by teaching them quantitative polymerase chain reaction (qPCR) as a way to quantify gene expression of chemical defense proteins in response to exposure to environmental pollutants. During the course, students are guided through the various…
Descriptors: High School Students, Science Instruction, Quality Control, Genetics
Ochs, Raymond – Biochemistry and Molecular Biology Education, 2019
Understanding redox reactions in biochemistry requires a clear grasp of three definitions: electron exchange, oxidation number, and oxygen atom insertion. Here, the electrochemical cell is explained for redox-active ions, introducing a new comparison between the measurement of midpoint potential and the measurement of initial velocity for enzymes.…
Descriptors: Biochemistry, Scientific Concepts, Concept Formation, Measurement