One of the greatest challenges in a student's ability to successfully complete reactions in organic chemistry is the ability to differentiate between reactions that have similar structures and proceed through similar reaction mechanisms. Featured in this article is an interleaved reaction review activity called a reaction web. Students are divided into teams and are presented with either a 4 × 2 or 4 × 3 matrix of randomly placed, interrelated structures and are tasked with discovering as many connections between structures in the matrix as they can, linking structures with an arrow beginning with reactants and ending with products. The necessary reagents for each connection are recorded in a separate table. The activity draws high participation from class members and provides many timely teaching moments.