The subject of pharmaceutical research has traditionally focused on drugs with systemic effects. However, contemporary approaches aspire to achieve targeted drug delivery, with the aim of combatting infections with a precise immune response. Active substances are encapsulated in nanoparticles, transported through the body, and selectively released…

Efforts to encourage laboratory automation through student access to and usage of commercial equipment are hampered by prohibitive acquisition costs. Here, an automated liquid handler using manual pipettes was developed to operate on a commercial hobbyist 3D printer at a cost of US $325. Arising from an iterative design process that ensured…

A major challenge when designing new experiments for the general chemistry laboratory is introducing students to the necessary techniques while keeping the experiment engaging and accessible. This work presents a new multiweek activity designed to introduce students to advanced instrumentation in the form of high-performance liquid chromatography…

An integrated laboratory experience in X-ray photoelectron spectroscopy (XPS) is designed for undergraduate and graduate students in chemistry, materials science, and other related fields. Focusing on ubiquitous Si, Cu, and their common oxides, students are guided to characterize a series of standard materials by XPS to understand the fundamentals…

Student engagement in evidence-based argumentation plays a central role in science education. These skills can be developed when identifying organic molecules from the spectroscopic data. Molecular structural analysis fosters deep procedural knowledge, as it involves (i) flexibly applying a set of procedures to extract information from spectra,…

The urea cycle disorder drug glycerol phenylbutyrate (Ravicti) is presently one of the most expensive medications in the United States, with annual costs estimated at $800,000 as of 2023. An expedient synthesis of this orphan drug was successfully adapted for the undergraduate organic chemistry laboratory. Activation of 4-phenylbutyric acid with…

As the 21st century progresses, we are increasingly reminded of the importance of and need for green chemistry, which also leads to the corresponding need for green chemistry education. The UC Berkeley Department of Chemistry developed a green chemistry laboratory curriculum-the "General Chemistry Green Curriculum" ("GC[superscript…

Owing to the critical role of stereochemistry in biotechnology, medicine, and industry, it must be well represented in undergraduate lab curricula. To achieve these stereochemical laboratory requirements without sacrificing existing lab techniques, we modified two standard laboratory experiments to include chiral GC analysis as follows. (1) The…

Herein we describe an accessible and safe at-home experiment to separate lycopene from tomatoes via liquid-liquid extraction. As a qualitative experiment, it is a canonically elementary instance for high school students to digest the conception of miscibility, immiscibility, and density difference of the two solvents. This experiment was performed…

We are all users of lithium-ion batteries (LIBs), the electrochemical energy storage devices that revolutionized our life, making the diffusion of portable and wearable devices possible and now driving the switch from a combustion engine to electric vehicles in the transportation sector. These positive trends are however leading to two whiplash…

Approximations can help to orient the student in an organic chemistry laboratory. There the student needs to develop the solvent systems for the reaction and isolation of organic reactants and products. The adage "like dissolves like" helps in this regard, but this approach is vague and entirely qualitative. More quantitative approaches…

Laboratory chemical synthesis research typically lacks the preplanned hazard responses found in production-scale industrial laboratories. Chemical safety management is a known challenge in education-based facilities, which is concerning for academic and national laboratory environments working with inexperienced student researchers. At the…

Stereoselective reduction of ketones to alcohols using baker's yeast is a classic experiment in the undergraduate laboratory. Here we illustrate the reduction of racemic ethyl 2-fluoro-3-oxobutanoate to the corresponding alcohol using a set of four commercially available ketoreductases (KREDs). The reaction sets two stereocenters with four…

A simple demonstration adaptable to classroom conditions is presented, which involves the preparation of raffle tickets using filter paper and the solution of selected fluorophores. With an appropriate dilution, the text written on the tickets is not visible to the naked eye; however, it becomes readable once put under a UV lamp. Besides being a…

A renewed experimental procedure for the unknown carbonyl experiment has been developed using hydrazone synthesis, thin layer chromatography (TLC) analysis, and melting point determination to differentiate between structurally similar ketones and aldehydes in undergraduate organic chemistry practical courses. Benzaldehyde, p-tolualdehyde,…