Project Lead the Way (PLTW) is an applied STEM program first introduced nearly three decades ago to enhance the STEM content of Career Technical Education (CTE). Currently, more than 12,000 US high schools offer the program. Using data from three cohorts of public high school freshmen in Missouri, we investigate the impact of PLTW program offer (ITT) and participation (TOT) on initial post-secondary outcomes. We use a difference-in-difference (DiD) analysis for ITT and a principal score adjusted DiD to estimate TOT. The parallel trends assumption is explicitly tested. We find positive ITT impacts on STEM major declaration among students with higher STEM preparation levels, and this outcome improved substantially for PLTW participants. Impacts on college enrollment are less conclusive.