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Murphy Angelo; Yash Bhargava; Scott Takeo Aoki – Biochemistry and Molecular Biology Education, 2024
The complexity of RNA cannot be fully expressed with the canonical A, C, G, and U alphabet. To date, over 170 distinct chemical modifications to RNA have been discovered in living systems. RNA modifications can profoundly impact the cellular outcomes of messenger RNAs (mRNAs), transfer and ribosomal RNAs, and noncoding RNAs. Additionally, aberrant…
Descriptors: Genetics, Biochemistry, Molecular Biology, College Science
Caryn Babaian; Sudhir Kumar; Sayaka Miura – American Biology Teacher, 2025
Water is one of the most common molecules in the universe. Water is polarized, but it has many states besides the normal tetrahedron depicted in standard biology texts. Water is also the most ubiquitous molecule on Earth, the universal solvent. It is the internal and external habitat of cells. Ecologically, water is contiguous with life and the…
Descriptors: Biology, Evolution, Science Instruction, Water
Hannah K. Parker; Beth Zizzamia; Julie A. Pollock – Journal of Chemical Education, 2025
In a typical undergraduate biochemistry course, two main educational objectives include (1) understanding and applying how genetic mutations can influence protein structure and function, and (2) examining metabolic pathways of biomolecules to study cellular storage and fuel. Many times, these topics can seem disparate to students; therefore, we…
Descriptors: Undergraduate Students, College Science, Science Instruction, Biochemistry
Caryn Babaian; Sudhir Kumar – American Biology Teacher, 2024
When students think of evolution, they might imagine T. rex, or perhaps an abiotic scene of sizzling electrical storms and harsh reducing atmospheres, an Earth that looks like a lunar landscape. Natural selection automatically elicits responses that include "survival of the fittest," and "descent with modification," and with…
Descriptors: Evolution, Science Education, Cancer, Teaching Methods
Karaismailoglu, Fatma; Yildirim, Mehtap – Biochemistry and Molecular Biology Education, 2023
This article presents the integration of Tinkercad, a free online modeling program that allows students to model molecular genetic concepts, into the distance learning process. The students had the opportunity to learn molecular genetics in a fun and more efficient way in spite of the limitations of the COVID-19 lockdown, and, in this respect, it…
Descriptors: Models, Genetics, Molecular Structure, Scientific Concepts
Evans, James P. – American Biology Teacher, 2022
Although unrecognized for his scientific achievements during his life, Gregor Mendel pioneered our modern understanding of the gene, work that shaped the field of genetics and advances in biology and medicine. The field that he set in motion 200 years ago lies at the center of current ethical debates about the future of humanity, the limits of…
Descriptors: Science History, Scientists, Heredity, Genetics
Jiro Kondo; Shota Nakamura – Journal of Chemical Education, 2023
The use of molecular models in chemistry and biochemistry classes is very effective in helping students understand covalent bonds and the chemical structure of molecules. However, conventional molecular models cannot represent intermolecular interactions such as hydrogen bonds and electrostatic interactions. Herein, we describe 3D printed…
Descriptors: Chemistry, Molecular Structure, Scientific Concepts, Biochemistry
Stephens, Isaiah O.; Thomas, Elizabeth M. – Journal of Chemical Education, 2022
Apurinic/apyrimidinic (AP or abasic) sites are deoxyribonucleic acid (DNA) lesions that result from the loss of a nucleobase by hydrolysis of the "N"-glycosyl bond. AP sites are the most frequent lesions in cells and are caused by environmental and cancer therapeutic genotoxins. Herein, the bicinchoninic colorimetric assay, typically…
Descriptors: Science Instruction, Chemistry, Genetics, Undergraduate Study
Cheplick, G. P. – Journal of Biological Education, 2021
A complex terminology developed around the evolutionary concept of adaptation. One definition of adaptation is synonymous with adaptive evolution and denotes a process of population change driven by natural selection resulting in individuals better able to survive and reproduce in a particular environment (compared to the population before the…
Descriptors: Semantics, Evolution, Scientific Concepts, Genetics
Goodsell, David S.; Zardecki, Christine; Berman, Helen M.; Burley, Stephen K. – Biochemistry and Molecular Biology Education, 2020
For 20 years, Molecule of the Month articles have highlighted the functional stories of 3D structures found in the Protein Data Bank (PDB). The PDB is the primary archive of atomic structures of biological molecules, currently providing open access to more than 150,000 structures studied by researchers around the world. The wealth of knowledge…
Descriptors: Biochemistry, Molecular Structure, Archives, Genetics
Keira D. Naff; Jeri L. Tyler; Dima H. Hamza; Jonathan D. White – Journal of Chemical Education, 2023
Structure--activity relationships are foundational concepts in biochemistry and drug design. Despite their importance, it can be difficult to create and execute laboratory activities that allow students to directly observe the interactions between small-molecule drugs and their biomolecular targets. Here, we report an activity that investigates…
Descriptors: Genetics, Undergraduate Students, Undergraduate Study, College Science
Ying-Chih Chen; Jongchan Park; Jamie G. Rapkiewcz – American Biology Teacher, 2024
Productive struggle is a process in which students expend effort to grapple with perplexing problems and make sense of something that is not immediately apparent and beyond their current level of understanding and capacity. The experience encourages students to reflect on and restructure their existing knowledge toward a new understanding of…
Descriptors: Error Correction, Biology, Science Education, Teaching Methods
Cedric Loretan; Andreas Mu¨ller – Journal of Chemical Education, 2023
The activity presented here is about an approximate or order-of-magnitude approach to information technology on the nano level, dealing in particular with the genetic code. Based on "There's Plenty of Room at the Bottom", the famous and visionary paper by Richard Feynman, the activity provides insight into a core concept of nanoscience…
Descriptors: Chemistry, Secondary School Science, High School Students, Science Activities
Brenner, Eric D.; Scheid, Paul E.; DeGrazia, Justin; Geltzeiler, Alexa R.; Katari, Manpreet S. – Biochemistry and Molecular Biology Education, 2021
Due to its distinct phenotype and relatively simple inheritance pattern, the phenylthiocarbamide (PTC) loci is frequently utilized in teaching laboratories to demonstrate genetic concepts such as Mendelian inheritance and population genetics. We have developed a next-generation sequencing and bioinformatics approach to analyze the PTC gene locus…
Descriptors: Science Instruction, Science Laboratories, Genetics, Teaching Methods
Haenel, Gregory – American Biology Teacher, 2023
Case studies are valuable tools for instruction but are often limited to a single topic and a single class period. Courses such as evolution that synthesize multiple concepts around a common theme, however, can use a single case study type project that extends over the entire semester to develop and link core concepts. A central theme in…
Descriptors: Science Instruction, Evolution, Biology, Genetics