Owing to factors such as poor water solubility of luminol and the instability and easy decomposition of hydrogen peroxide (H[subscript 2]O[subscript 2]), the accuracy and sensitivity of the detection of H[subscript 2]O[subscript 2] through the luminol electrochemiluminescence (ECL) system are limited. Herein, we propose a water-soluble…

Chirality continues to intrigue scientists because of its implications in various scientific areas, including the long-unsolved question of its development and link with the origin of life. Chirality plays a significant role in medicine with the advent of chiral drugs and the consequent importance of asymmetric synthesis. For many undergraduate…

Paal--Knorr reactions are a classical method for synthesizing pyrroles, using 1,4-dicarbonyl compound and amine as reactants. It has the characteristics of green chemistry, as only two molecules of water are lost. In this teaching and learning experiment, 2,5-hexanedione and 4-"tert"-butylaniline were used to synthesize…

Knowledge of scientific principles and practices is vital to creating informed citizens. At its core, science helps create citizens who question the why and how of things, while also increasing knowledge of the world and beyond. Humans by nature are curious and thrive when they are engaged in learning that relates to real-world situations relevant…

The complexity of RNA cannot be fully expressed with the canonical A, C, G, and U alphabet. To date, over 170 distinct chemical modifications to RNA have been discovered in living systems. RNA modifications can profoundly impact the cellular outcomes of messenger RNAs (mRNAs), transfer and ribosomal RNAs, and noncoding RNAs. Additionally, aberrant…

The measurement of glucose through electrochemical methods is a great example to illustrate the practical application of electrochemistry. Although many students enrolled in chemistry classes are familiar with the glucose meter, only a few have delved into the underlying principles governing its operation. This experiment aims to address this gap…

Education in organic chemistry is highly reliant on molecular representations. Students abstract information from representations to make sense of submicroscopic interactions. This study investigates relationships between differing representations: bond-line structures, ball-and-stick, or electrostatic potential maps (EPMs), and predicting partial…

The urea cycle disorder drug glycerol phenylbutyrate (Ravicti) is presently one of the most expensive medications in the United States, with annual costs estimated at $800,000 as of 2023. An expedient synthesis of this orphan drug was successfully adapted for the undergraduate organic chemistry laboratory. Activation of 4-phenylbutyric acid with…

The increasing popularity of mobile devices as alternative tools for learning has led to the adoption of virtual laboratory simulation (VLab) to enhance practical learning experiences. This paper introduces an interactive mobile learning application designed to facilitate medical students in learning ear anatomy using a three-dimensional model.…

Owing to the critical role of stereochemistry in biotechnology, medicine, and industry, it must be well represented in undergraduate lab curricula. To achieve these stereochemical laboratory requirements without sacrificing existing lab techniques, we modified two standard laboratory experiments to include chiral GC analysis as follows. (1) The…

Liquid metals are widely applied in various fields, including chemistry, catalysis, energy storage, chemical sensing, and stretchable electronics, due to their unique deformabilities. However, their behavior under a rod or ring electrode has never been analyzed. Furthermore, research on the deformation behavior of eutectic Ga--In (EGaIn), the most…

A novel teaching approach is aimed at elucidating the concept of bond enthalpy for general chemistry students. Through the integration of a hands-on candy pulling activity, students in a large lecture class were provided a tangible experience to explore bond strengths using rope candy and a luggage scale. Feedback from students indicated a clear…

Future needs and challenges, especially in complex real-world problem-solving, require education to equip individuals with quality skills. Inquiry-based learning that integrates socio-scientific issues (SSI) can significantly develop students' problem-solving skills. This study aims to test the effects of the Socio-Scientific Real-world Inquiry…

Anaerobic respiration reactions are of fundamental importance to global biogeochemical cycling of elements. Yet, the idea that cellular respiration can occur not only in the absence of oxygen but also involve the oxidation of inorganic substrates (e.g., AsO[subscript 3 superscript 3-], Fe[superscript 2+], H[subscript 2], H[subscript 2]S,…

In this second-semester organic chemistry lab experiment, students work collaboratively using a combination of chemical synthesis and NMR spectroscopy to investigate the diastereoselectivity associated with the Meerwein-Ponndorf-Verley (MPV) reduction of two ketone substrates having carbonyl groups flanked by an [alpha]-chiral carbon with…