Green fluorescent protein has long been a favorite protein for demonstrating protein purification in the biochemistry lab course. The protein's vivid green color helps demonstrate to students the concept(s) behind affinity or ion exchange chromatography. We designed a series of introduction to biochemistry labs utilizing a thermostable green…

A major challenge when designing new experiments for the general chemistry laboratory is introducing students to the necessary techniques while keeping the experiment engaging and accessible. This work presents a new multiweek activity designed to introduce students to advanced instrumentation in the form of high-performance liquid chromatography…

Lakes are artists' pigments made from colorants bound to an inert substrate, usually hydrated aluminum oxide. Before the late 19th century, lakes were made from natural pigments extracted from plants and insects, extracted either directly from the dyestuff or indirectly from waste materials generated in the manufacture of dyed textiles. The first…

This experiment demonstrates that copper(II) chloride dihydrate (CuCl[subscript 2]·2H[subscript 2]O) in different solvents (acetone, isopropyl alcohol, or water) displays divergent colors and visible-near IR spectra. Both the reactions of these solutions with 2 equiv of sodium hydroxide (NaOH) and the direct solid-state reaction of CuCl[subscript…

There is an increasing need for fundamental electrochemistry concepts to be taught in the undergraduate curriculum, given the broad applicability of electrochemical technologies in addressing a wide range of global issues from critical energy shortages to real-time medical diagnostics. However, many electrochemical concepts are often taught in…

A new organic chemistry experiment aimed to separate the chlorophyll precursor in plant seeds by column chromatography is described. The primary pedagogical goal in developing this experiment is to establish a simple and interesting chromatographic separation to demonstrate basic concepts and the standard procedure for this important lab…

So-called "Color Wonder" markers contain colorless dyes that only display color when used to mark on special "Color Wonder" paper. These markers make use of leuco dyes that only develop color in the presence of acid. These markers provide science educators with a novel chemical system that can be implemented in inquiry-based…

Undergraduate-level laboratory experiments that integrate multidisciplinary chemistry concepts into a single activity are very appealing and thought-provoking for chemistry students. Here, we use the oscillating chemical reaction to introduce students to the analytical detection concept. The Belousov-Zhabotinsky reaction is employed as a simple…

The laboratory experiment presented here describes the use of a calcium ion-selective electrode (Ca-ISE) to determine the concentration of zinc in a supplement tablet. This approach was developed to show students how to expand the range of applications of Ca-ISE to enable the determination of metal ions other than Ca[superscript 2+]. To determine…

Colorful transitions of various acid-base indicators have been used to illustrate the concept of chemical equilibria, especially in spectrophotometric determination of the equilibrium constants or pKa values. To accommodate an online laboratory environment necessitated by the COVID-19 pandemic, this work employs color analyses from digital images…

The identification of coloring substances is a relevant task in the field of conservation and restoration, but it can be challenging as in real samples the target analytes are inserted in a very complex matrix made of binders and additives. Understanding this concept is fundamental for upper-division undergraduate students interested in…

During the pandemic caused by SARS-CoV-2 (COVID-19), a paper analytical device (PAD) was proposed as a tool for remote laboratory classes for undergraduate chemistry to teach calibration curve concepts. For this experiment, students were taught how to prepare a PAD, calibrate standard solutions, construct a calibration curve, and treat data…

We have developed a multivariate and multidisciplinary lab experiment on the synthesis of alginate hydrogel beads of various sizes and dye encapsulation for upper-division undergraduate and graduate students. This experiment introduces students to several common concepts in polymer chemistry, materials science, and drug delivery. The experiment…

Mobile phones are a widely used platform for educational apps, mobile health, and a variety of chemical tests. Here, we are working on a mobile phone-based physics lab (mPhysics) that uses a mobile phone's capabilities to run simple physics experiments and demonstrations. While a mobile phone can be used to analyze magnetic and optical properties…

A new undergraduate inorganic chemistry laboratory experiment is presented. An introduction of the spectrochemical series and ligand exchange is explored using the coordination complex dirhodium tetraacetate, Rh[subscript 2](OAc)[subscript 4]. Students have measured the absorption spectra of the Rh[subscript 2] complex in the presence of various…