Structure--activity relationships are foundational concepts in biochemistry and drug design. Despite their importance, it can be difficult to create and execute laboratory activities that allow students to directly observe the interactions between small-molecule drugs and their biomolecular targets. Here, we report an activity that investigates…

The activity presented here is about an approximate or order-of-magnitude approach to information technology on the nano level, dealing in particular with the genetic code. Based on "There's Plenty of Room at the Bottom", the famous and visionary paper by Richard Feynman, the activity provides insight into a core concept of nanoscience…

Students tend to think of their science courses as isolated and unrelated to each other, making it difficult for them to see connections across disciplines. In addition, many existing science assessments target rote memorization and algorithmic problem-solving skills. Here, we describe the development, implementation, and evaluation of an activity…

Many biology students struggle to learn about the process of meiosis and have particular difficulty understanding the molecular basis of crossing over and the importance of homologous pairing for proper segregation. To help students overcome these challenges, we designed an activity that uses a newly developed Chromosome Connections Kit® from 3-D…

A set of core ideas in the life sciences revolve around genetics, variation, and inheritance. While the "Next Generation Science Standards" (NGSS; NGSS Lead States 2013) emphasize teaching and learning about these concepts across K-12 grades, it is critical for early learners to begin to develop understanding of them. By the end of fifth…

The use of modeling-based instruction is very effective when learning science content in multiple disciplines for native speakers. However, the benefits of using this pedagogy with students learning English as a second language or English Learners (ELs) have not been widespread, especially at the upper secondary level. This article discusses the…

A novel experiment has been developed with a goal of enhancing engagement and deepening understanding of fundamental molecular biology concepts. In this laboratory activity, students investigate the composition of pet foods through quantitative polymerase chain reaction (qPCR) analysis. By conducting this experiment, students address a scientific…

Biocatalysis is a fundamental concept in biotechnology. The topic integrates knowledge of several disciplines; therefore, it was included in the course "design and optimization of biological systems" which is offered in the biochemistry curricula. We selected the ciliate tetrahymena as an example of a eukaryotic system with potential for…

How much do students really know about chromosomes? This article describes a partner activity and then a whole-class activity that use modeling to teach DNA replication, connect it to the shape of chromosomes during mitosis, and help students understand how daughter cells have the same DNA. Modeling is integral to science, helping students…

Problem-based learning (PBL) fosters both content knowledge and content understanding, improves critical and process thinking skills, and promotes peer-to-peer learning, leadership, and teamwork (Hmelo-Silver 2004). Instructors support the PBL process by guiding students through activities that challenge their current knowledge and understanding…

Although engineering design is dependent upon the use of science and mathematics, the actual prototype, model, or solution that pre-college students generate can be accomplished without the students explicitly using scientific or mathematical concepts. It is therefore important to explore how students apply science and mathematics concepts when…

The Bold Fold, which is presented in this article, is a 45-minute activity in which students create a protein model while learning the processes of transcription, translation, protein folding, and delivery, which are often difficult to understand and have led to common misconceptions (Wright, Fisk, and Newman 2014). This activity has been used…

We describe a structured inquiry laboratory exercise that examines transcriptional regulation of the "NOS2" gene under conditions that simulate the inflammatory response in macrophages. Using quantitative PCR and the comparative C[subscript T] method, students are able determine whether transcriptional activation of "NOS2"…

Teachers are being challenged to engage students in ways that will elevate student interest and understanding of concepts in science and encourage students to gather evidence to support what we know about science. It is critical for teachers to have budget-friendly, supporting activities that are aligned with current educational standards, that…

In this two-part activity, high school biology students examine human karyotyping, sex-chromosome-linked disorders, and the relationship between biological sex and gender. Through interactive simulations and a structured discussion lab, students create a human karyotype and diagnose chromosomal disorders in hypothetical patients, as well as…