Green fluorescent protein has long been a favorite protein for demonstrating protein purification in the biochemistry lab course. The protein's vivid green color helps demonstrate to students the concept(s) behind affinity or ion exchange chromatography. We designed a series of introduction to biochemistry labs utilizing a thermostable green…

A major challenge when designing new experiments for the general chemistry laboratory is introducing students to the necessary techniques while keeping the experiment engaging and accessible. This work presents a new multiweek activity designed to introduce students to advanced instrumentation in the form of high-performance liquid chromatography…

Liquid metals are widely applied in various fields, including chemistry, catalysis, energy storage, chemical sensing, and stretchable electronics, due to their unique deformabilities. However, their behavior under a rod or ring electrode has never been analyzed. Furthermore, research on the deformation behavior of eutectic Ga--In (EGaIn), the most…

In this two-session experiment for an organic chemistry lab, students prepare a macrocyclic host compound--namely, a pillar[5]arene--by means of a templated 1,4-dimethoxybenzene/formaldehyde cyclo-oligomerization (session 1), and then, they explore its molecular recognition properties toward the 1,8-diaminooctane guest with the aid of [superscript…

Educational content is consistently adapted to enhance the learning experience of students at all experience and skill levels. Student motivation and accessibility are key factors in teaching science to a broad audience. The presented experiments engage the students by relating the content to that which is immediately relevant to them: the threat…

High-resolution mass spectrometry (HRMS) is an analytical technique that is typically used by mass spectrometry experts. However, with recent advancements, it is becoming more accessible to students in organic chemistry laboratories. Still, a significant knowledge gap exists between these experts and students. A straightforward laboratory…

The addition of a small excess of triethyl orthoformate to an alcoholic mixture of NiCl[subscript 2]·6H[subscript 2]O and triphenylphosphine (PPh[subscript 3]) results in an increase in the typical isolated yield of [NiCl[subscript 2](PPh[subscript 3])[subscript 2]] from below 50% to over 85%. The impact of water when present in the reaction…

Lakes are artists' pigments made from colorants bound to an inert substrate, usually hydrated aluminum oxide. Before the late 19th century, lakes were made from natural pigments extracted from plants and insects, extracted either directly from the dyestuff or indirectly from waste materials generated in the manufacture of dyed textiles. The first…

Most students enter college without any exposure to polymer science, which leads to the poor understanding and slow implementation of plastic recycling programs in the United States. To address the knowledge gap in chemical recycling, we introduce a 2-part laboratory experiment that was conducted in multiple high schools and public outreach events…

In this laboratory experiment, a guided inquiry exploring the physicochemical principles of the dissolution of Ca(OH)[subscript 2](s) in water is proposed for laboratory classes in university and high school. As part of students' inquiry, two experimental approaches are used. One is the change in solubility with temperature revealed by measuring…

An undergraduate laboratory experiment has been developed for the synthesis of a reactive cross-linker that is useful in various highly visual demonstrations of organic reactivity, click chemistry, and biobased polymer synthesis. A triazolinedione-based cross-linker, which is known as a useful reagent for click chemistry, can be obtained from…

The carbonyl group of an aldehyde or ketone reacts with different types of nucleophiles through a nucleophilic addition reaction. When the nucleophile is water, the product obtained is a "gem"-diol or geminal diol. This functionalization is unstable and quickly reverts to the parent carbonyl group. The chemistry of "gem"-diols…

The Ouchterlony double immunodiffusion technique is used as a teaching tool for studying immune responses and exemplifying differences in antigen-antibody reactions. Although commonplace in undergraduate labs, standardized commercial kits limit learning experiences because they have fixed modalities of use, a low shelf-life, and impose budgetary…

Understanding the basics of d-electron configuration and the spin state of coordination complexes are essential elements of undergraduate inorganic chemistry. However, students in these courses find it difficult to conceptualize the ideas. Here, we have developed an undergraduate laboratory experiment that allows students to systematically…

CACAO (Chocolate Across the Curriculum and Outreach) is a vertical curriculum augmentation designed to help students across the ChE undergraduate program. The students use a chocolate-based food engineering lab to make connections between core chemical engineering topics using hands-on and project-based learning. Costs to create this component are…