This study is rigorous of peer-reviewed literature on the integration of information and communication technology (ICT) tools in secondary schools. It analyzed the impact of ICT integration on the teaching and learning process based on 51 sampled studies. The findings are thematically presented under the benefits of improving teaching and learning processes regarding curriculum coverage, equitable access, shared learning resources, and personalized learning. Furthermore, challenges were found in professional development, pedagogical and technological knowledge, and resource maintenance. Among the best practices and strategies to resolve these challenges were regular supply and systems maintenance, curricula realignment, ICT policy formulation, and engaging all stakeholders in ICT integration. Recommendations: practitioners should adopt, adapt, and innovate pedagogical approaches, strategies, and methods to facilitate the use of ICT in teaching and learning and should align and integrate ICT tools with curriculum objectives, content, or standards by exploring and using diverse and dynamic ICT tools and methods in secondary schools.