This study examined a model in which the need for reassurance from others and the capacity for self-reinforcement mediated the relationships between two dimensions of perfectionism (evaluative concerns [EC] perfectionism and personal standards [PS] perfectionism) and anxiety and depression. Results from structural equation modeling of data from 295 college students from a large midwestern university indicated that the need for reassurance from others and the capacity for self-reinforcement fully mediated the relationship between EC perfectionism and anxiety as well as partially mediated the relationships between PS perfectionism and anxiety and depression. Moreover, 41% of the variance in anxiety and 50% of the variance in depression was explained by EC perfectionism, PS perfectionism, the need for reassurance from others, and/or the capacity for self-reinforcement. (Contains 3 figures, 5 tables and 3 footnotes.)