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Pasco, Greg; Davies, Kim; Ribeiro, Helena; Tucker, Leslie; Allison, Carrie; Baron-Cohen, Simon; Johnson, Mark H.; Charman, Tony – Journal of Autism and Developmental Disorders, 2021
Parents participating in a prospective longitudinal study of infants with older siblings with autism completed an autism screening questionnaire and were asked about any concerns relating to their child's development, and children were administered an interactive assessment conducted by a researcher at 14 months. Scores on the parent questionnaire…
Descriptors: Questionnaires, Parents, Infants, Autism
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Salomone, Erica; Shephard, Elizabeth; Milosavljevic, Bosiljka; Johnson, Mark H.; Charman, Tony; Baron-Cohen, Simon; Bedford, Rachael; Bolton, Patrick; Chandler, Susie; Elsabbagh, Mayada; Fernandes, Janice; Garwood, Holly; Gliga, Teodora; Hudry, Kristelle; Jones, Emily J. H.; Pasco, Greg; Pickles, Andrew; Tucker, Leslie; Volein, Agnes – Journal of Autism and Developmental Disorders, 2018
Cognitive and adaptive behaviour abilities early in life provide important clinical prognostic information. We examined stability of such skills in children at high familial risk for ASD who either met diagnostic criteria for ASD at age 7 years (HR-ASD, n = 15) or did not (HR-non-ASD, n = 24) and low-risk control children (LR, n = 37),…
Descriptors: Children, At Risk Persons, Cognitive Ability, Behavior Problems
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Milosavljevic, Bosiljka; Shephard, Elizabeth; Happé, Francesca G.; Johnson, Mark H.; Charman, Tony – Journal of Autism and Developmental Disorders, 2017
Anxiety and threat bias were examined in 6-8-year-old children at familial-risk for Autism Spectrum Disorder (ASD) and low-risk (LR, n = 37) controls. The high-risk (HR) group was divided into those who met diagnostic criteria for ASD (HR-ASD, n = 15) and those who did not (HR-non ASD, n = 24). The HR-ASD group had highest levels of…
Descriptors: Pervasive Developmental Disorders, Autism, Anxiety, At Risk Students
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Thomas, Michael S. C.; Davis, Rachael; Karmiloff-Smith, Annette; Knowland, Victoria C. P.; Charman, Tony – Developmental Science, 2016
This article outlines the "over-pruning hypothesis" of autism. The hypothesis originates in a neurocomputational model of the regressive sub-type (Thomas, Knowland & Karmiloff-Smith, 2011a, 2011b). Here we develop a more general version of the over-pruning hypothesis to address heterogeneity in the timing of manifestation of ASD,…
Descriptors: Autism, Pervasive Developmental Disorders, Computer Simulation, Symptoms (Individual Disorders)
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Johnson, Mark H.; Gliga, Teodora; Jones, Emily; Charman, Tony – Journal of Child Psychology and Psychiatry, 2015
Background: Autism spectrum disorders (ASD) and attention deficit hyperactivity disorder (ADHD) are two of the most common neurodevelopmental disorders, with a high degree of co-occurrence. Methods: Prospective longitudinal studies of infants who later meet criteria for ASD or ADHD offer the opportunity to determine whether the two disorders share…
Descriptors: Autism, Attention Deficit Hyperactivity Disorder, Pervasive Developmental Disorders, Symptoms (Individual Disorders)
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Wan, Ming Wai; Green, Jonathan; Elsabbagh, Mayada; Johnson, Mark; Charman, Tony; Plummer, Faye – Research in Developmental Disabilities: A Multidisciplinary Journal, 2012
Recent models of the early emergence of autism spectrum disorder (ASD) propose an interaction between risk susceptibility and the infant's social environment, resulting in a progressively atypical developmental trajectory. The infant's early social environmental experience consists mostly of interaction with caregivers, yet there has been little…
Descriptors: Infants, Siblings, Risk, Autism
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Bedford, Rachael; Pickles, Andrew; Gliga, Teodora; Elsabbagh, Mayada; Charman, Tony; Johnson, Mark H. – Developmental Science, 2014
Emerging findings from studies with infants at familial high risk for autism spectrum disorder (ASD), owing to an older sibling with a diagnosis, suggest that those who go on to develop ASD show early impairments in the processing of stimuli with both social and non-social content. Although ASD is defined by social-communication impairments and…
Descriptors: Infants, Autism, Attention, Eye Movements
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Green, Jonathan; Wan, Ming Wai; Guiraud, Jeanne; Holsgrove, Samina; McNally, Janet; Slonims, Vicky; Elsabbagh, Mayada; Charman, Tony; Pickles, Andrew; Johnson, Mark – Journal of Autism and Developmental Disorders, 2013
Theory and evidence suggest the potential value of prodromal intervention for infants at risk of developing autism. We report an initial case series (n = 8) of a parent-mediated, video-aided and interaction-focused intervention with infant siblings of autistic probands, beginning at 8-10 months of age. We outline the theory and evidence base…
Descriptors: Intervention, At Risk Persons, Infants, Autism
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Messinger, Daniel; Young, Gregory S.; Ozonoff, Sally; Dobkins, Karen; Carter, Alice; Zwaigenbaum, Lonnie; Landa, Rebecca J.; Charman, Tony; Stone, Wendy L.; Constantino, John N.; Hutman, Ted; Carver, Leslie J.; Bryson, Susan; Iverson, Jana M.; Strauss, Mark S.; Rogers, Sally J.; Sigman, Marian – Journal of the American Academy of Child & Adolescent Psychiatry, 2013
Objective: First-degree relatives of persons with an autism spectrum disorder (ASD) are at increased risk for ASD-related characteristics. As little is known about the early expression of these characteristics, this study characterizes the non-ASD outcomes of 3-year-old high-risk (HR) siblings of children with ASD. Method: Two groups of children…
Descriptors: Outcome Measures, Autism, Early Intervention, Siblings
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Leonard, Hayley C.; Bedford, Rachael; Charman, Tony; Elsabbagh, Mayada; Johnson, Mark H.; Hill, Elisabeth L. – Autism: The International Journal of Research and Practice, 2014
Recently, evidence of poor or atypical motor skills in autism spectrum disorder has led some to argue that motor impairment is a core feature of the condition. The current study uses a longitudinal prospective design to assess the development of motor skills of 20 children at increased risk of developing autism spectrum disorder, who were…
Descriptors: Motor Development, At Risk Students, Autism, Infants
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Gliga, Teodora; Senju, Atsushi; Pettinato, Michèle; Charman, Tony; Johnson, Mark H. – Developmental Psychology, 2014
The recent development in the measurements of spontaneous mental state understanding, employing eye-movements instead of verbal responses, has opened new opportunities for understanding the developmental origin of "mind-reading" impairments frequently described in autism spectrum disorders (ASDs). Our main aim was to characterize the…
Descriptors: Autism, Pervasive Developmental Disorders, Siblings, Cognitive Processes
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Elsabbagh, Mayada; Volein, Agnes; Holmboe, Karla; Tucker, Leslie; Csibra, Gergely; Baron-Cohen, Simon; Bolton, Patrick; Charman, Tony; Baird, Gillian; Johnson, Mark H. – Journal of Child Psychology and Psychiatry, 2009
Background: Recent studies of infant siblings of children diagnosed with autism have allowed for a prospective approach to examine the emergence of symptoms and revealed behavioral differences in the broader autism phenotype within the early years. In the current study we focused on a set of functions associated with visual attention, previously…
Descriptors: Autism, Infants, Siblings, Control Groups
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Yirmiya, Nurit; Charman, Tony – Journal of Child Psychology and Psychiatry, 2010
Autism is one of the most heritable neurodevelopmental conditions and has an early onset, with symptoms being required to be present in the first 3 years of life in order to meet criteria for the "core" disorder in the classification systems. As such, the focus on identifying a prodrome over the past 20 years has been on pre-clinical…
Descriptors: Symptoms (Individual Disorders), Autism, Infants, Genetics