Real data are unlikely to be exactly normally distributed. Ignoring non-normality will cause misleading and unreliable parameter estimates, standard error estimates, and model fit statistics. For non-normal data, researchers have proposed a distributionally-weighted least squares (DLS) estimator to combines the normal theory based generalized…

The analysis of cross-lagged relationships is a popular approach in prevention research to explore the dynamics between constructs over time. However, a limitation of commonly used cross-lagged models is the requirement of equally spaced measurement occasions that prevents the usage of flexible longitudinal designs and complicates cross-study…

The purpose of this paper is to extend and evaluate methods of "Bayesian historical borrowing" applied to longitudinal data with a focus on parameter recovery and predictive performance. Bayesian historical borrowing allows researchers to utilize information from previous data sources and to adjust the extent of borrowing based on the…

The purpose of this paper is to extend and evaluate methods of "Bayesian historical borrowing" applied to longitudinal data with a focus on parameter recovery and predictive performance. Bayesian historical borrowing allows researchers to utilize information from previous data sources and to adjust the extent of borrowing based on the…

We consider Bayesian estimation of a hierarchical linear model (HLM) from small sample sizes. The continuous response Y and covariates C are partially observed and assumed missing at random. With C having linear effects, the HLM may be efficiently estimated by available methods. When C includes cluster-level covariates having interactive or other…

Social network data often contain missing values because of the sensitive nature of the information collected and the dependency among the network actors. As a response, network imputation methods including simple ones constructed from network structural characteristics and more complicated model-based ones have been developed. Although past…

The performance of statistical methods is often evaluated by means of simulation studies. In case of network meta-analysis of binary data, however, simulations are not currently available for many practically relevant settings. We perform a simulation study for sparse networks of trials under between-trial heterogeneity and including multi-arm…

Throughout the different phases of a drug development program, randomized trials are used to establish the tolerability, safety and efficacy of a candidate drug. At each stage one aims to optimize the design of future studies by extrapolation from the available evidence at the time. This includes collected trial data and relevant external data.…

Statistical thinking is essential to understanding the nature of scientific results as a consumer. Statistical thinking also facilitates thinking like a scientist. Instead of emphasizing a "correct" procedure for data analysis and its outcome, statistical thinking focuses on the process of data analysis. This article reviews frequentist…

Meta-analyses of clinical trials targeting rare events face particular challenges when the data lack adequate numbers of events for all treatment arms. Especially when the number of studies is low, standard random-effects meta-analysis methods can lead to serious distortions because of such data sparsity. To overcome this, we suggest the use of…

In the coming years, public programs will capture even more and richer data than they do now, including data from web-based tools used by participants in employment services, from tablet-based educational curricula, and from electronic health records for Medicaid beneficiaries. Program evaluators seeking to take full advantage of these data…

Lord's Wald test for differential item functioning (DIF) has not been studied extensively in the context of the multidimensional item response theory (MIRT) framework. In this article, Lord's Wald test was implemented using two estimation approaches, marginal maximum likelihood estimation and Bayesian Markov chain Monte Carlo estimation, to detect…

Modeling the distribution of site level effects is an important problem, but it is also an incredibly difficult one. Current methods rely on distributional assumptions in multilevel models for estimation. There it is hoped that the partial pooling of site level estimates with overall estimates, designed to take into account individual variation as…

A new variant of the iterative "data = fit + residual" data-analytical approach described by Mosteller and Tukey is proposed and implemented in the context of item response theory psychometric models. Posterior probabilities from a Bayesian mixture model of a Rasch item response theory model and an unscalable latent class are expressed…

The multilevel latent class model (MLCM) is a multilevel extension of a latent class model (LCM) that is used to analyze nested structure data structure. The nonparametric version of an MLCM assumes a discrete latent variable at a higher-level nesting structure to account for the dependency among observations nested within a higher-level unit. In…