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Removal of S6K1 and S6K2 Leads to Divergent Alterations in Learning, Memory, and Synaptic Plasticity
Peer reviewed
Direct linkAntion, Marcia D.; Merhav, Maayan; Hoeffer, Charles A.; Reis, Gerald; Kozma, Sara C.; Thomas, George; Schuman Erin M.; Rosenblum, Kobi; Klann, Eric – Learning & Memory, 2008
Protein synthesis is required for the expression of enduring memories and long-lasting synaptic plasticity. During cellular proliferation and growth, S6 kinases (S6Ks) are activated and coordinate the synthesis of de novo proteins. We hypothesized that protein synthesis mediated by S6Ks is critical for the manifestation of learning, memory, and…
Descriptors: Animals, Memory, Biology, Fear
Howard, Marc W.; Fotedar, Mrigankka S.; Datey, Aditya V.; Hasselmo, Michael E. – Psychological Review, 2005
The medial temporal lobe (MTL) has been studied extensively at all levels of analysis, yet its function remains unclear. Theory regarding the cognitive function of the MTL has centered along 3 themes. Different authors have emphasized the role of the MTL in episodic recall, spatial navigation, or relational memory. Starting with the temporal…
Descriptors: Recall (Psychology), Memory, Brain Hemisphere Functions, Simulation
Download full textKosslyn, Stephen M. – 1985
Visual recognition, navigation, tracking, and imagery are posited to involve some of the same types of representations and processes. The first part of this paper develops a theory of some of the shared types of representations and processing modules. The theory is developed in light of neurophysiological and neuroanatomical data from non-human…
Descriptors: Behavior Patterns, Cerebral Dominance, Conceptual Tempo, Elementary Secondary Education
