High sugar diets reduce hippocampal neurogenesis, which is required for minimizing interference between memories, a process that involves "pattern separation." We provided rats with 2 h daily access to a sucrose solution for 28 d and assessed their performance on a spatial memory task. Sucrose consuming rats discriminated between objects…

Hippocampal-dependent episodic memory and stimulus discrimination abilities are both compromised in the elderly. The reduced capacity to discriminate between similar stimuli likely contributes to multiple aspects of age-related cognitive impairment; however, the association of these behaviors within individuals has never been examined in an animal…

Severe amblyopia, characterized by a significant reduction in visual acuity through the affected eye, is highly resistant to reversal in adulthood. We have previously shown that synaptic plasticity can be reactivated in the adult rat visual cortex by dark exposure, and the reactivated plasticity can be harnessed to promote the recovery from severe…

Episodic memories for autobiographical events that happen in unique spatiotemporal contexts are central to defining who we are. Yet, before 2 years of age, children are unable to form or store episodic memories for recall later in life, a phenomenon known as infantile amnesia. Here, we studied the development of allocentric spatial memory, a…

In this experiment we studied statistical learning, inter-trial priming, and visual attention. We assessed healthy controls and right brain damaged (RBD) patients with and without neglect, on a simple visual discrimination task designed to measure priming effects and probability learning. All participants showed a preserved priming effect for item…

Attention and working memory are fundamental for selecting and maintaining behaviorally relevant information. Not only do both processes closely intertwine at the cognitive level, but they implicate similar functional brain circuitries, namely the frontoparietal and the frontostriatal networks, which are innervated by cholinergic and dopaminergic…

Event-related brain potentials (ERPs) were recorded while participants (n=13) were presented with mirrored and normal letters at different orientations and were asked to make mirror-normal letter discriminations. As it has been suggested that a mental rotation out of the plane might be necessary to decide on mirrored letters, we wanted to…

Recent work has shown that Whorf effects of language on color discrimination are stronger in the right visual field than in the left. Here we show that this phenomenon is not limited to color: The perception of animal figures (cats and dogs) was more strongly affected by linguistic categories for stimuli presented to the right visual field than…

Successful interaction with the environment depends upon our ability to retain and update visuo-spatial information of both front and back egocentric space. Several studies have observed that healthy people tend to show a displacement of the egocentric frame of reference towards the left. However representation of space behind us (back space) has…

Two experiments investigated whether the representations used for animal, produce, and object recognition code spatial relations in a similar manner. Experiment 1 tested the effects of planar rotation on the recognition of animals and nonanimal objects. Response times for recognizing animals followed an inverted U-shaped function, whereas those…

Visual-spatial orienting in 10 high-functioning adults with autism was examined. Compared to controls, subjects responded faster to central than to lateral stimuli, and showed a left visual field advantage for stimulus detection only when laterally presented. Abnormalities in attention shifting and coordination of attentional and motor systems are…