A critical role of protein modifications such as phosphorylation and acetylation in synaptic plasticity and memory is well documented. Tyrosine sulfation plays important roles in several biological processes. However, its role in synaptic plasticity and memory is not well understood. Here, we show that sulfation contributes to long-term…

It has been shown that the left and right cerebral hemispheres (LH and RH) respectively process qualitative or "categorical" spatial relations and metric or "coordinate" spatial relations. However, categorical spatial information could be thought as divided into two types: semantically-coded and visuospatially-coded categorical information. We…

Converging behavioral and neural evidence suggests that numerical representations are mentally organized in left-to-right orientation. Here we show that this format of spatial organization extends to emotional expression. In Experiment 1, right-side responses became increasingly faster as number (represented by Arabic numerals) or happiness…

In patients with the callosal type of anarchic-hand syndrome, the left hand often does not act as intended and counteracts the right hand. Reports are scarce about the underlying neurophysiological mechanisms. We report the case G.H. who developed the syndrome after infarction of the left arteria pericallosa. It has been suggested that the…

It is well established that glucocorticoid hormones strengthen the consolidation of hippocampus-dependent spatial and contextual memory. The present experiments investigated glucocorticoid effects on the long-term formation of conditioned taste aversion (CTA), an associative learning task that does not depend critically on hippocampal function.…

The present investigation concerns the integrity of a primary mental function, the egocentric frame of reference and the sense of polarity of one's own head. The visually perceived eye level (VPEL) and the subjective antero-posterior axis of the head were measured by means of a visual indicator in darkness during two stimulus conditions: static…

K. Wiegand and E. Wascher (2005) used the lateralized readiness potential (LRP) to investigate the mechanisms underlying spatial stimulus-response (S-R) correspondence. The authors compared spatial S-R correspondence effects obtained with horizontal and vertical S-R arrangements. In some relevant previous investigations on spatial S-R…

Some recent evidence suggests that mental rotation of characters in children aged 7 or 8 years might be lateralized to the left parietal hemisphere. An alternative statement exists, however, the finding might be completely unspecific for mental rotation but either be simply a function of task difficulty or a consequence of the use of characters as…

We find a spatially asymmetric allocation of attention in patients with traumatic brain injury (TBI) despite the lack of obvious asymmetry in neurological indicators. Identification performance was measured for simple spatial patterns presented briefly to a locus 5 degrees into the left or right hemifield, after precuing attention to the same…

We investigated the role of acetylcholine (ACh) during encoding and retrieval of tone/shock-induced fear conditioning with the aim of testing Hasselmo's cholinergic modulation model of encoding and retrieval using a task sensitive to hippocampal disruption. Lesions of the hippocampus impair acquisition and retention of contextual conditioning with…

Highly variable bisection performance in neglect patients has been attributed to an increased "zone of indifference" (Marshall & Halligan, 1989). The indifference zone indicates the discrepancy between two line lengths which are judged as equal in length. Following this argumentation, the central area of a line should be expanded in neglect…