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"N"-Heterocyclic Carbene-Catalyzed Reaction of Chalcone and Cinnamaldehyde to Give 1,3,4-Triphenylcyclopentene Using Organocatalysis to Form a Homoenolate Equivalent
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Snider, Barry B. – Journal of Chemical Education, 2015
In this experiment, students carry out a modern organocatalytic reaction using IMes·HCl and NaOH to catalyze the formation of 1,3,4-triphenylcyclopentene from cinnamaldehyde and chalcone in water. Deprotonation of IMes·HCl with NaOH forms the "N"-heterocyclic carbene IMes that reacts with cinnamaldehyde to form a homoenolate equivalent…
Descriptors: Science Instruction, Science Experiments, Scientific Concepts, College Science
Metalloprotease Peptide Inhibitors: A Semester-Long Organic Synthetic Research Project for the Introductory Laboratory Course
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Pontrello, Jason K. – Journal of Chemical Education, 2015
A semester-long research project to synthesize unique compounds designed after published metalloprotease peptide inhibitors is presented. The research project encompasses a set of nine organic chemistry reactions traditionally taught in the second semester lab course, and the procedures are derived from scientific literature. The two principle…
Descriptors: Science Instruction, Organic Chemistry, Science Laboratories, Laboratory Experiments
Development and Validation of the Light and Spectroscopy Concept Inventory
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Bardar, Erin M.; Prather, Edward E.; Brecher, Kenneth; Slater, Timothy F. – Astronomy Education Review, 2007
This article describes the development and validation of the Light and Spectroscopy Concept Inventory (LSCI), a 26-item diagnostic test designed (1) to measure students' conceptual understanding of topics related to light and spectroscopy, and (2) to evaluate the effectiveness of instructional interventions in promoting meaningful learning gains…
Descriptors: Astronomy, Science Instruction, College Science, Test Construction