This research paper aims to propose a novel didactic sequence inspired by an historical/epistemological study of the evolution of spectroscopy and in particular of colorimetry. The working principles of the historical color comparators and the visual color matching method, first proposed by Duboscq, stimulated us in the development of a five-step…

The ability to elucidate the structure of organic compounds from their nuclear magnetic resonance (NMR), infrared (IR), and mass spectrometry (MS) spectra is an essential skill, particularly for those engaged in the fields of synthetic and analytical organic chemistry. Spectral analysis constitutes a fundamental component of the curriculum for all…

A straightforward protocol for the preparation of the colorful and air-stable diphenyl ditelluride is described. In one laboratory session, students isolate their product and characterize it via melting point determination, mass spectrometry, and NMR spectroscopy ([superscript 1]H, [superscript 13]C­{[superscript 1]H}, and [superscript…

We here propose a simple and fast hands-on activity requiring limited equipment, to introduce students of various levels (bachelor's or high school) and backgrounds (from science to arts) to the chemistry of color. The different colors of stained glass are replicated through the deposition, on ordinary glass slides, of silica coatings colored by…

A laboratory project to introduce upper-level undergraduates to Pd-catalyzed C-N [sigma]-bond forming reactions is described. The exercise involves evaluation of monodentate phosphine ligands and solvents for the Buchwald-Hartwig coupling of 4-chloro-or 4-bromo-anisole with morpholine. Students gain experience in the synthesis of a biarylphosphine…

Chemometric techniques such as partial least-squares (PLS) regression have been applied with huge success to a wide array of chemical problems including multicomponent analysis of analytes in complex mixtures. Despite this, there are few examples of laboratory pedagogical exercises that involve students in the acquisition of chemical data from…

Optics is one of the subject areas in which students have difficulty learning. Establishing the right connections between the concepts of optics and daily life supports the learning of the concepts of optics. In addition, this connection increases the students' motivation to learn optical issues. In this study, three activities related to prisms…

UV-vis absorption spectroscopy is one of the most accessible spectroscopic techniques at the high school educational level, and it is usually introduced in analytical chemistry courses due to its high versatility and to the wide range of applications in many fields of chemistry. Within this framework, we have developed an easy-to-use"…

Techniques from the branch of artificial intelligence known as machine learning (ML) have been applied to a wide range of problems in chemistry. Nonetheless, there are very few examples of pedagogical activities to introduce ML to chemistry students in the chemistry education literature. Here we report a computational activity that introduces…

Lecture-only chemistry courses without a dedicated laboratory component present a significant challenge for instructors to reinforce course content with hands-on learning experiences. This is especially true for lecture courses in which students are unable to directly visualize and operate instrumentation. Herein, we present an in-class activity…

An easily constructed and inexpensive polarimeter with an optical rotation angle resolution of about 0.5° is presented. It is made from small pieces of polarizing film, 2 LEDs, a protractor, and a few wires, all held in place with plastic interlocking toy bricks, such as Lego bricks. The instrument was used to demonstrate the optical rotation of…

This inquiry-based lesson gets students moving to simulate chemical reactions in a way that allows them to visualize, understand, and retain information about chemical reactions in the stratosphere. Students then look at scientific data and conduct research to understand trends in the data and the impact of chlorofluorocarbons (CFCs). These…

An experiment for the synthesis of N-acyl derivatives of natural amino acids has been developed as part of the Distributed Drug Discovery (D3) program. Students use solid-phase synthesis techniques to complete a three-step, combinatorial synthesis of six products, which are analyzed using LC-MS and NMR spectroscopy. This protocol is suitable for…

In recent years, nanotechnology has been one of the major subjects of scientific and technological research. Currently, several applications of nanotechnologies are already available on the market. Particularly relevant are the fields of new materials and sensors, which have excellent potential future applications in the biomedical field. This…

In this paper, we report an experiment intended as a tool to introduce chemistry and materials science students to several chemical concepts through the determination of the best experimental conditions for the formation of calcium oxide (lime) from a source of high content of calcium carbonate (eggshells). Thermal gravimetric analysis (TGA),…