A fast, operationally simple, and reproducible synthetic protocol for anthraquinone dyes (AQDs), suitable for upper-division undergraduate industrial and organic chemistry laboratory courses, has been developed. This experiment is composed of three stages; the first step deals with the synthesis of AQDs, followed by a purification step, and…

Spectrometers play a decisive role in the education of A-level and/or under-graduate students in the field of natural sciences. They are capable to demonstrate atomic emission, transmission, reflection and fluorescence spectra, but can be used for wavelength filtering, as well. Here, we present a do-it-yourself spectrometer setup based on a…

A straightforward procedure for the synthesis of (Ph[subscript 3]P)[subscript 3]CuCF[subscript 3], a robust, air-stable trifluoromethylating agent, is reported herein. This preparation can be completed in a single 3 h laboratory session and typically provides ample yields (~79--86%) and high purity (>90%). The target complex is characterized by…

Nuclear magnetic resonance (NMR) spectroscopy is a very powerful analytical method that has found many applications in physics, chemistry, biology, and medicine. It is an indispensable tool particularly for synthetic chemists because it can be used for a rapid elucidation of the structures of organic compounds. For this reason, NMR spectral…

Plant-derived natural products are an important source of potential medicines and continue to have a major impact on the drug discovery process. Natural product discovery assignments provide an opportunity to present various experimental techniques to undergraduate students in introductory medicinal chemistry. This assignment was developed to…

The aroma volatile compounds in tomatoes are strongly linked to taste and flavor. Commercial tomato varieties, however, generally lack flavor. Tomato breeding programs have therefore started to focus on increasing the flavor-enhancing volatiles, which can be more easily altered than the sugar content. Analytical efforts that identify key flavor…

The redox reaction between dioxovanadium(V) and oxalate is proposed as a suitable system to analyze the kinetics of a twostep reaction mechanism using UV-vis spectroscopy. First, the spectra of dioxovanadium(V) and its reduced counterpart oxovanadium(IV) are compared and explained using the crystal field theory. The change in absorbance can be…

The synthesis of 4-amino-3-nitrobenzoic acid methyl ester is a simple Fischer esterification reaction designed as an experiment for use in an introductory organic chemistry course. The compound was synthesized as a one-pot reaction within 30 min to 16 h, with 1 h producing a workable yield. The bright-yellow solid was purified using liquid--liquid…

Raman spectroscopy is an important vibrational spectroscopy tool to characterize chemical compounds. As only a few photons undergo Raman scattering, enhancement of signal is a vital requirement. In this laboratory experiment, some practical aspects of Raman spectroscopy and how a simple enhancement procedure can be used to detect a Raman signal…

The spectrophotometric determination of the percent composition of an aspirin tablet is a common first-year, general chemistry undergraduate laboratory procedure. The experiment requires that a known amount of pure acetylsalicylic acid be quantitatively converted into the soluble disodium salicylic acid that is further reacted with excess…

Keto-enol tautomerism is a fundamental concept that examines the migration of a proton between two constitutional isomers, the keto and enol tautomer. Many experiments have been proposed to understand the concept behind Meyer's Rule, which states that the keto tautomer is favored as the solvent polarity increases. However, all the experiments have…

The aldol condensation reaction is one of the many synthesis reactions carried out in second semester organic chemistry laboratories. This reaction was integrated into a novel experiment requiring students to synthesize dibenzalace tone derivatives using the crossed-aldol condensation by reacting different types of benzaldehyde derivatives with…

This paper reports the development and application of a low-cost multifunctional webcam spectrophotometer for the conduct of molecular absorption and fluorometric measurements. The equipment, which costs approximately US$20 to be fabricated, consists of a webcam, a diffraction grating, and a slit, all positioned inside an MDF box. Spectral…

Techniques and instrumentation that involve fluorescence are used in many careers related to biology and biochemistry. However, due to the expense of instrumentation, the theory and practice of fluorescence spectroscopy is commonly concentrated in instrumental analysis in most curricula, a class rarely required for biology and biochemistry majors.…

During the last 40 years, neuroscience has become one of the most central and most productive approaches to investigating autism. In this commentary, we assemble a group of established investigators and trainees to review key advances and anticipated developments in neuroscience research across five modalities most commonly employed in autism…