Proposed is a new method of standard setting referred to as response vector for mastery (RVM) method. Under the RVM method, the task of panelists that participate in the standard setting process does not involve conceptualization of a borderline examinee and probability judgments as it is the case with the Angoff and bookmark methods. Also, the RVM-based computation of a cut-score is not based on a single item (e.g., marked in an ordered item booklet) but, instead, on a response vector (1/0 scores) on items and their parameters calibrated in item response theory or under the recently developed "D"-scoring method. Illustrations with hypothetical and real-data scenarios of standard setting are provided and methodological aspects of the RVM method are discussed.