Researchers face many choices when conducting large-scale multisite individually randomized control trials. One of the most common quantities of interest in multisite RCTs is the overall average effect. Even this quantity is non-trivial to define and estimate. The researcher can target the average effect across individuals or sites. Furthermore,…

We consider two-level models where a continuous response R and continuous covariates C are assumed missing at random. Inferences based on maximum likelihood or Bayes are routinely made by estimating their joint normal distribution from observed data R[subscript obs] and C[subscript obs]. However, if the model for R given C includes random…

Applying single-level statistical models to multilevel data typically produces underestimated standard errors, which may result in misleading conclusions. This study examined the impact of ignoring multilevel data structure on the estimation of item parameters and their standard errors of the Rasch, two-, and three-parameter logistic models in…

To plan cluster-randomized trials with sufficient statistical power to detect intervention effects on student achievement, researchers need multilevel design parameters, including measures of between-classroom and between-school differences and the amounts of variance explained by covariates at the student, classroom, and school level. Previous…

Multilevel data are a reality for many disciplines. Currently, although multiple options exist for the treatment of multilevel data, most disciplines strictly adhere to one method for multilevel data regardless of the specific research design circumstances. The purpose of this Monte Carlo simulation study is to compare several methods for the…

In multilevel multiple-indicator multiple-cause (MIMIC) models, covariates can interact at the within level, at the between level, or across levels. This study examines the performance of multilevel MIMIC models in estimating and detecting the interaction effect of two covariates through a simulation and provides an empirical demonstration of…

When a multisite randomized trial reveals between-site variation in program impact, methods are needed for further investigating heterogeneous mediation mechanisms across the sites. We conceptualize and identify a joint distribution of site-specific direct and indirect effects under the potential outcomes framework. A method-of-moments procedure…

Multilevel models (MLMs) have proven themselves to be very useful in social science research, as data from a variety of sources is sampled such that individuals at level-1 are nested within clusters such as schools, hospitals, counseling centers, and business entities at level-2. MLMs using restricted maximum likelihood estimation (REML) provide…

The hierarchical network model (HNM) is a framework introduced by Sweet, Thomas, and Junker for modeling interventions and other covariate effects on ensembles of social networks, such as what would be found in randomized controlled trials in education research. In this article, we develop calculations for the power to detect an intervention…

Mediation in multi-level data can be examined using conflated multilevel modeling (CMM), unconflated multilevel modeling (UMM), or multilevel structural equation modeling (MSEM). A Monte Carlo study was performed to compare the three methods on bias, type I error, and power in a 1-1-1 model with random slopes. The three methods showed no…

Designs that facilitate inferences concerning both the total and indirect effects of a treatment potentially offer a more holistic description of interventions because they can complement "what works" questions with the comprehensive study of the causal connections implied by substantive theories. Mapping the sensitivity of designs to…

The impact of misspecifying covariance matrices at the second and third levels of the three-level model is evaluated. Results indicate that ignoring existing covariance has no effect on the treatment effect estimate. In addition, the between-case variance estimates are unbiased when covariance is either modeled or ignored. If the research interest…

Modeling the distribution of site level effects is an important problem, but it is also an incredibly difficult one. Current methods rely on distributional assumptions in multilevel models for estimation. There it is hoped that the partial pooling of site level estimates with overall estimates, designed to take into account individual variation as…

When cluster randomized experiments are analyzed as if units were independent, test statistics for treatment effects can be anticonservative. Hedges proposed a correction for such tests by scaling them to control their Type I error rate. This article generalizes the Hedges correction from a posttest-only experimental design to more common designs…

The design of research studies utilizing binary multilevel models must necessarily incorporate knowledge of multiple factors, including estimation method, variance component size, or number of predictors, in addition to sample sizes. This Monte Carlo study examined the performance of random effect binary outcome multilevel models under varying…