Causal mediation analysis has gained increasing attention in recent years. This article guides empirical researchers through the concepts and challenges of causal mediation analysis. I first clarify the difference between traditional and causal mediation analysis and highlight the importance of adjusting for the treatment-by-mediator interaction…

In the article, we focused on the issues of measurement error and omitted confounders while conducting mediation analysis under experimental studies. Depending on informativeness of the confounders between the mediator (M) and outcome (Y), we described two approaches. When researchers are confident that primary confounders are included (e.g.,…

In causal mediation studies that decompose an average treatment effect into indirect and direct effects, examples of post-treatment confounding are abundant. In the presence of treatment-by-mediator interactions, past research has generally considered it infeasible to adjust for a post-treatment confounder of the mediator-outcome relationship due…

Mediation has played a critical role in developmental theory and research. Yet, developmentalists rarely discuss the methodological challenges of establishing causality in mediation analysis or potential strategies to improve the identification of causal mediation effects. In this article, we discuss the potential outcomes framework from…

Empirical studies often demonstrate multiple causal mechanisms potentially involving simultaneous or causally related mediators. However, researchers often use simple mediation models to understand the processes because they do not or cannot measure other theoretically relevant mediators. In such cases, another potentially relevant but unobserved…

When designing a study for causal mediation analysis, it is crucial to conduct a power analysis to determine the sample size required to detect the causal mediation effects with sufficient power. However, the development of power analysis methods for causal mediation analysis has lagged far behind. To fill the knowledge gap, I proposed a…

Research questions regarding how, for whom, and where a treatment achieves its effect on an outcome have become increasingly valued in substantive research. Such questions can be answered by causal moderated mediation analysis, which assesses the heterogeneity of the mediation mechanism underlying the treatment effect across individual and…

This observational, cross-sectional study examined students' retrospective recall of emotional distress when studying sensitive topics in psychology, and whether hardiness had a mediated pathway to emotional distress through a mental health condition (MHC). Psychology undergraduates (155 women, 34 men) from South Australian universities completed…

Purpose: The purpose of this paper is to conduct a critical review of the mediation studies published in the field of Human Resource Development (HRD) to discern if the study designs, the nature of data collection and the choice of statistical methods justify the causal claims made in those studies. Design/methodology/approach: This paper conducts…

This article presents marginal structural models with inverse propensity weighting (IPW) for assessing mediation. Generally, individuals are not randomly assigned to levels of the mediator. Therefore, confounders of the mediator and outcome may exist that limit causal inferences, a goal of mediation analysis. Either regression adjustment or IPW…