This paper reviews the use of multiple trials, defined as multiple sites or multiple arms in a single evaluation and replications, in evaluating social programs. After defining key terms, the paper discusses the rationales for conducting multiple trials, which include increasing sample size to increase statistical power; identifying the most…

Evidence-based policy at the local level requires predicting the impact of an intervention to inform whether it should be adopted. Increasingly, local policymakers have access to published research evaluating the effectiveness of policy interventions from national research clearinghouses that review and disseminate evidence from program…

Network meta-analysis compares multiple treatments in terms of their efficacy and harm by including evidence from randomized controlled trials. Most clinical trials use parallel design, where patients are randomly allocated to different treatments and receive only 1 treatment. However, some trials use within person designs such as split-body,…

Design-based methods have recently been developed as a way to analyze randomized controlled trial (RCT) data for designs with a single treatment and control group. This article builds on this framework to develop design-based estimators for evaluations with multiple research groups. Results are provided for a wide range of designs used in…

Design-based methods have recently been developed as a way to analyze data from impact evaluations of interventions, programs, and policies (Freedman, 2008; Lin, 2013; Imbens and Rubin, 2015; Schochet, 2013, 2016; Yang and Tsiatis, 2001). The non-parametric estimators are derived using the building blocks of experimental designs with minimal…

Recent methods have sought to improve precision in randomized controlled trials (RCTs) by utilizing data from large observational datasets for covariate adjustment. For example, consider an RCT aimed at evaluating a new algebra curriculum, in which a few dozen schools are randomly assigned to treatment (new curriculum) or control (standard…

Background/Context: When a researcher tests an educational program, product, or policy in a randomized controlled trial (RCT) and detects a significant effect on an outcome, the intervention is usually classified as something that "works." When the expected effects are not found, however, there is seldom an orderly and transparent…

The purpose of this paper is to present results of recent advances in power analyses to detect the moderator effects in Cluster Randomized Trials (CRTs). This paper focus on demonstration of the software PowerUp!-Moderator. This paper provides a resource for researchers seeking to design CRTs with adequate power to detect the moderator effects of…

Conventionally, regression discontinuity analysis contrasts a univariate regression's limits as its independent variable, "R," approaches a cut point, "c," from either side. Alternative methods target the average treatment effect in a small region around "c," at the cost of an assumption that treatment assignment,…

Researchers are often interested in whether the effects of an intervention differ conditional on individual- or group-moderator variables such as children's characteristics (e.g., gender), teacher's background (e.g., years of teaching), and school's characteristics (e.g., urbanity); that is, the researchers seek to examine for whom and under what…

Recently, there has been an increase in the number of cluster randomized trials (CRTs) to evaluate the impact of educational programs and interventions. These studies are often powered for the main effect of treatment to address the "what works" question. However, program effects may vary by individual characteristics or by context,…

To plan cluster-randomized trials with sufficient statistical power to detect intervention effects on student achievement, researchers need multilevel design parameters, including measures of between-classroom and between-school differences and the amounts of variance explained by covariates at the student, classroom, and school level. Previous…

Recent studies show cluster randomized trials may be well powered to detect mediation or indirect effects in multilevel settings. However, literature has rarely provided guidance on designing cluster-randomized trials aim to assess indirect effects. In this study, we developed closed-form expression to estimate the variance of and the statistical…

Data from cluster randomized trials do not always have a pure hierarchical structure. For instance, students are nested within schools that may be crossed by neighborhoods, and soldiers are nested within army units that may be crossed by mental health-care professionals. It is important that the random cross-classification is taken into account…

In basic regression discontinuity (RD) designs, causal inference is limited to the local area near a single cutoff. To strengthen the generality of the RD treatment estimate, a design with multiple cutoffs along the assignment variable continuum can be applied. The availability of multiple cutoffs allows estimation of a pooled average treatment…